introduction: introduction: leucocytes accounted for 26-36% of the stromal cells in decidua of the first trimester of gestation in which 75% of them is related to endometrial granulated lymphocytes (egl) with an unusual natural killer (nk) cell-like phenotype. different roles are proposed for egl, but fundamental role of these cells in control for normrly underestood. material and methods: in t...

Immunoglobulins were eluted from ovine placentae and characterized by immunoprecipitation, electrophoresis, western blotting and ELISA. IgG was shown to comprise the bulk of placental-bound immunoglobulins while smaller amounts of IgM and only trace amounts of IgA were demonstrated. Results suggest that ovine placental IgG eluted by surgical cannulation of the uterine blood vessels in situ is s...

Normal human fetal development requires an adequate supply of thyroid hormone from conception. Until about 16 wk gestation this is supplied entirely by placental transfer of maternal hormone. Subsequently, the fetal thyroid synthesizes thyroid hormones, requiring a supply of maternal iodide. Trophoblast iodide transfer is mediated by the apical sodium iodide symporter (NIS). Placental oxygen le...

Abstract Background As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate involves many types of placental cells, such as trophoblasts, mesenchymal stem cells. There has been no systematic, comparative study on roles these two groups cells whole tissue in angiogenesis. In this study, primary cytotrop...

Objectives: to determine morphological and immunohistochemical changes in the placentas of displaced pregnant women order further improve antenatal monitoring program.Materials methods. 96 (the main group) took part prospective study, who depending on therapy were divided into: group I – 65 monitored according generally accepted recommendations received routine for prolonging pregnancy, II 31 p...

In process of placentation, expression of various glycoproteins has important role in embryonal development. Alterations of DNA methylation caused by 5-azacytidine (5azaC) can disturb normal glycoproteins expression as well as proliferative ability of trophoblast cells. In order to assess that, a single dose of 5azaC was injected intraperitoneally to pregnant rats during the day 1 to 19 of gest...

The placenta grows rapidly for a short period with high blood flow during pregnancy and has multifaceted functions, such as its barrier function, nutritional transport, drug metabolizing activity and endocrine action. Consequently, the placenta is a highly susceptible target organ for drug- or chemical-induced adverse effects, and many placenta-toxic agents have been reported. However, histopat...

It is increasingly recognized that vitamin D3 (VitD3) has an anti-inflammatory activity. The present study investigated the effects of maternal VitD3 supplementation during pregnancy on LPS-induced placental inflammation and fetal intrauterine growth restriction (IUGR). All pregnant mice except controls were intraperitoneally injected with LPS (100 μg/kg) daily from gestational day (GD)15-17. I...

Placental and fetal tissues from 46 human pregnancies were cultured and cytogenetically analyzed in an attempt to document the existence of chromosomal mosaicism confined strictly to tissues of extraembryonic origin. In two gestations in which chromosomal mosaicism was found, it was expressed exclusively in placental chorionic cells and was not detected in cells derived from the embryo proper. ...

Background: Pre-eclampsia (PE) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. Imbalance in helper T cell functions may play a role in predisposing to PE or severity of the disease. Elevated frequencies of Th17 cells in the peripheral blood of PE patients have been reported. Several single nucleotide polymorphisms (SNP) within ...