BACKGROUND Etravirine (ETR; also known as TMC125) is a new nonnucleoside reverse-transcriptase inhibitor with activity against wild-type and nonnucleoside reverse-transcriptase inhibitor-resistant human immunodeficiency virus type 1 (HIV-1). METHODS This randomized, phase IIb, placebo-controlled, 2-stage, dose-escalating trial evaluated the safety, tolerability, and preliminary efficacy of 3 ...

the purpose of this study was to investigate the effects of short term creatine monohydrate as an ergogenic supplement on the sprint performance and muscular strength of wrestlers. 20 wrestlers were selected randomly and divided into two groups. one group was placebo group (control) and the other group was creatine supplement group (experimental). in a double blind project, subjects' speed...

objective: premenstrual syndromes (pms) affecting 20-40% of women of reproductive age. the aim of this double blind and placebo controlled trial was to investigate whether femicofort a supplement contains vitamin b6, vitamin e and evening primrose oil could relieve symptoms of pms. method: this was a randomized and double blind clinical trial. the trial was conducted between november 2009 and a...

Aim: This study aimed to verify the acute effect of photobiomodulation (PBM) on maximal lactate production rate (VLamax) in front crawl swimmers. Methods: Fifteen male swimmers (20.9 ± 2.4-year-old) participated this study. Three sets crawls were performed at distances 100-, 200- and 400-m under three experimental conditions: PBM (420 J), placebo (PLA) control (C) randomized, crossover, double-...

Abstract Background The oral small molecule obefazimod (ABX464) has demonstrated efficacy and safety in patients with moderate-to-severe ulcerative colitis (UC) a randomized, placebo-controlled, 8-week phase 2b induction study1. We examined the effects of on miR-124 cytokines levels blood (baseline, weeks 4 8) rectal biopsies week these patients. Methods Absolute quantification (QuantaSoft Pro)...

Background: Fibromyalgia is a chronic disease characterized by widespread pain and severe fatigue that may be triggered reactivation of latent herpes simplex virus type 1 (HSV-1). In Phase 2a proof concept trial, IMC-1 (a fixed dose combination famciclovir celecoxib) demonstrated greater tolerability statistically significant reduction in compared with placebo, as measured change from baseline ...

Vitamin D deficiency is associated with cardiovascular and metabolic diseases. Cardiovascular diseases, in turn, are responsible for mortality of patients with type 2 diabetes (T2D). We investigated whether a single parenteral dose of 25(OH) Vit D could improve the endothelial function in T2D patients with ischemic heart disease. A randomized, placebo-controlled, and double-blind trial was perf...

Few thorough comparisons of the systemic effects of inhaled corticosteroids in children are available. The aim of this study was to compare the effect of budesonide and fluticasone propionate on short-term lower leg growth. Fluticasone propionate, budesonide and placebo were administered for 2 weeks in a randomized, double-blind, double-dummy, cross-over design. Twenty four children aged 6-12 y...

Objective: There are some studies about the good effects of herbal medicine on blood glucose. This study was designed to evaluate the synergism effect of Peganum Harmala (P.harmala), Quercus Infectoria (Q.i), Vaccinium Myrtillus (V.myrtillus), Citrullos Colocynthis (C.colocynthis), Securigera Securidaca (S.s) on blood glucosein type 2 diabetic patients. Materials and Methods: Twenty four type ...