In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...

The lateral entorhinal cortex (LEC) is thought to bind sensory events with the environment where they took place. To compare the relative influence of transient events and temporally stable environmental stimuli on the firing of LEC cells, we recorded neuron spiking patterns in the region during blocks of a trace eyeblink conditioning paradigm performed in two environments and with different co...

We examine the activity of individual neurons in three different brain areas where firing rate, number of spikes (the integral of discharge rate), and the location of the active cell within a motor map are used as coding schemes. The correlations between single cell activity and the parameters of a movement range from extremely tight (motoneurons) to non-existent (superior colliculus). We argue...

In general, experts involved in research on neural coding agree that information in nervous system is encoded in the spatio-temporal patterns of spikes. However, there are two distinct opinions about the manner in which this encoding takes place. Some experts consider that temporal coding is based on the exact timing of spiking activity of a single neuron whilst others believe that this encodin...

It is increasingly apparent that neurodegeneration in multiple sclerosis (MS) begins earlier in the course of the disease than was previously believed. The loss of axons, which results in permanent deficits, is distributed beyond regions of abnormal-appearing CNS white matter, and a constant background of neuron loss continues to take place while clinical symptoms wax and wane. It is therefore ...

On the linear track, the recent firing sequences of CA1 place cells recur during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster & Wilson (2006) Nature, 440, 680-683]. We have found similar reverse-order reactivation during SWRs in open-field exploration where the firing sequence of cells varied before each SWR. Both the onset times and the firing patterns of cells showed ...

introduction cholinergic system is one of the important systems of mammalian cns. cholinergic neurons distributed in brain and spinal cord and contributed to principal functions like: consciousness, learning and memory, and motor control. in this study we investigated the differentiation potentiality of mouse embryonic stem cells toward cholinergic neurons. the aim of this study was to evaluate...

objective(s) motor deficit and neuron degeneration is seen after nerve transection. the aim of this study is to determine whether a poled polyvinelidene fluoride (pvdf) tube with other supportive strategies can protect the neuronal morphology and motor function after sciatic nerve transaction in rats. materials and methods after transection of the left sciatic nerve in 60 male wistar rats (200-...

this paper addresses synchronizing two coupled chaotic fitzhugh–nagumo (fhn) neurons with weakly gap junction under external electrical stimulation (ees). to transmit information among coupled neurons, by generalization of the integer-order fhn equations of the coupled system into the fractional-order in frequency domain using crone approach, the behavior of each coupled neuron relies on its pa...