PRIMARY OBJECTIVE There are only limited data regarding pituitary functions in the acute phase of traumatic brain injury (TBI) and previous studies have been conducted in only small cohorts of subjects. Therefore we have investigated the pituitary functions in the early acute phase, within 24 hours of trauma, in 104 patients with TBI. Additionally, the relationships between basal pituitary horm...

Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3':5'-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E(1) also inc...

The a-subunit is common to the family of heterodimeric glycoprotein hormones FSH, LH, TSH and the placerual chorionic gonadotropin (CG). Clones coding for the pre a-subunit of the pituitary glycoprotein hormones were isolated from a lamb pituitary XgtlO cDNA library [1] using a synthetic oligonucleotide probe based on the published amino acid sequence of the ovine a-subunit [2] and nucleotide s...

Vasopressin and oxytocin were measured by radioimmunoassay in rat posterior pituitary and microdissected hypothalamic areas after 3 and 10 days of oral 2 percent sodium chloride in place of drinking water. There was a significant decrease in concentration of both hormones in posterior pituitary and in specific areas of the hypothalamus. Supraoptic, paraventricular, and arcuate hypothalamic nucl...

In the infantile animal the reproductive organs gradually develop but do not begin to function as organs of reproduction until the age of puberty, although their internal secretions begin before this time. In the female the cause for their functioning lies outside the ovary itself, for immature ovaries transplanted into adults begin to function immediately, whereas adult ovaries transplanted in...

Stress stimulates several adaptive hormonal responses. Prominent among these responses are the secretion of catecholamines from the adrenal medulla, corticosteroids from the adrenal cortex, and adrenocorticotropin from the anterior pituitary. A number of complex interactions are involved in the regulation of these hormones. Glucocorticoids regulate catecholamine biosynthesis in the adrenal medu...

Pituitary adenomas are the most common tumours in the central nervous system, make up approximately 10% of all primary intracerebral tumours [1] and are found incidentally in 3-27% of autopsies [2]. The predisposition to tumour formation of the highly specialized cellular phenotypes that characterize the anterior pituitary is unexplained, but it is tempting to speculate that the same hormones, ...

IT is well known that the human glycoprotein hormone family is comprised of four members: thyro-tropin (TSH) and gonadotropin (Gn), which includes follicle stimulating hormone (FSH), luteinizing hormone (LH) and chorionic gonadotropin (CG) [1, 2]. As shown in Fig. 1, synthesis and secretion of TSH, FSH and LH from the pituitary gland are regulated by the hypothalamic releasing hormones, thyrotr...

The production of betok fish has experienced overfishing and resulted in a decrease productivity, therefore one the efforts made to help success spawning can be done by stimulating factors related reproductive system, namely work hormones gonadal maturation artificial with hypophysation method. This study aims look at response goat pituitary extract fecundity (A. testudineus, Bloch). research w...

This report deals with a detailed course of one patient with acromegaly who had a pituitary apoplexy. The pituitary apoplexy occurred suddenly 5 days after administration of a oral hypoglycemic agent, buformin, during hospitalization. Immediately after the attack changes of the concentrations of several hormones such as serum growth-hormone, serum thyroid hormone and urinary 17-hydroxycorticoid...