The DIVA (Data IntensiVe Architecture) system incorporates Processing-In-Memory (PIM) chips as smart-memory coprocessors to a microprocessor, with a separate memory-to-memory interconnect, thus exploiting the inherent memory bandwidth both on chip and across the system. DIVA targets several classes of bandwidth-limited applications, including multimedia applications and pointer-based and sparse...

Tumor cells have higher rates of glucose uptake and aerobic glycolysis to meet energy demands for proliferation and metastasis. The characteristics of increased glucose uptake, accompanied with aerobic glycolysis, has been exploited for the diagnosis of cancers. Although much progress has been made, the mechanisms regulating tumor aerobic glycolysis and energy production are still not fully und...

Host signal-transduction pathways are intimately involved in the switch between latency and productive infection of herpes viruses. As with other herpes viruses, infection by Kaposi's sarcoma herpesvirus (KSHV) displays these two phases. During latency only few viral genes are expressed, while in the productive infection the virus is reactivated with initiation of extensive viral DNA replicatio...

The serine/threonine Pim kinases are overexpressed in solid cancers and hematologic malignancies and promote cell growth and survival. Here, we find that a novel Pim kinase inhibitor, SMI-4a, or Pim-1 siRNA blocked the rapamycin-sensitive mammalian target of rapamycin (mTORC1) activity by stimulating the phosphorylation and thus activating the mTORC1 negative regulator AMP-dependent protein kin...

Mycobacterium tuberculosis is a facultative intracellular pathogen that parasitizes macrophages by modulating properties of the Mycobacterium-containing phagosome. Mycobacterial phagosomes do not fuse with late endosomal/lysosomal organelles but retain access to early endosomal contents by an unknown mechanism. We have previously reported that mycobacterial phosphatidylinositol analog lipoarabi...

The human PIM-1 gene, a homologue of murine retroviral insertion site mpim-1, is overexpressed in a subset of hematolymphoid malignancies. Deduced amino acid sequence of PIM-1 complementary DNA predicts it to be a protein kinase. In vitro transcription coupled translation of the putative 313-amino acid open reading frame yields a Mr 34,000 protein; an immune complex kinase assay of the wild-typ...

This paper introduces how to apply OMG’s Model-Driven Architecture (MDA) to develop a cross-platform workflow solution. A workflow solution first is modeled as a PIM Platform Independent Model model. The PIM model will be translated into a PSM (Platform Specific Model) model according to the selected workflow platform and then the corresponding process definition is automatically generated. I...

The performance of dual heard pulse interval modulation (DH-PIM) employing least mean square error equaliser (LMSE) in diffuse infrared indoor environment is presented. The work is based on the ceiling bounce channel model and the Monte Carlos simulation. A 3-tap LMSE equaliser is used and results are compared with unequalised DH-PIM and with DH-PIM employing linear zero forcing equaliser (L-ZF...

In this paper DH-PIM modulation scheme and its properties are discussed. Expressions for, symbol length, transmission capacity, bandwidth requirements, photocurrent, power spectral density and slot and packet error rates are presented. Results obtained for the packet error rate are compared with OOK and PIM. It offers the same performance as PIM but considerably better performance compared with...

This research aims to investigate the possibility of electrospun fibers from Polymers of Intrinsic Microporosity (PIM-1) as an alternative adsorbent for aniline removal from both air and aqueous solution. Adsorption properties of electrospun PIM-1 fibers were compared with powder and film form of PIM-1. While electrospun PIM-1 nanofibrous mat can adsorb 871 mg g-1 aniline from air, it can also ...