Specific pig breeds with unique characteristics have been developed, and the current study sought to characterize some of these differences. Using modified Ussing chambers, electrophysiological mucosal transport of D-glucose, L-Gln, L-Pro, L-Arg, L-Thr, and glycylsarcosine was assessed in small intestinal tissues (duodenum, jejunum, ileum) taken from Yorkshire-based hybrid (BW = 142.4 +/- 2.0 k...

Considering the clinical significance of opioids, especially their application for the treatment of severe painful conditions including cancer pain and the requirement for the synthesis of more specific drugs with lower side effects, this study was conducted to perform a preliminary investigation on six newly developed opioid drugs. Our aim was to introduce drugs that act selectively on the opi...

Due to the increasing usage of herbal medicines and natural products for the body function management and ailments treatment and the lack of study on the beneficial effect of Herba Swertiae, a widely used traditional herbal medicine, this paper aimed to investigate the effect of Herba Swertiae on gastrointestinal system in vivo. The effect of Herba Swertiae on gastric emptying and intestinal pr...

The plant Asparagus racemosus is used traditionally in Kenya for a variety of medicinal purposes including the management pain, asthma, and premature labour. However, dearth empirical studies means that there limited information on acute toxicity pharmacological effects to support these uses by local plant. aim this study was, therefore, evaluate toxicity, analgesic, smooth muscle relaxation aq...

BACKGROUND The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal pain. OBJECTIVE The present study was undertaken to evaluate safety and spasmolytic effect of poly-herbal formulation. MATERIALS AND METHODS ...

The effects of various smooth muscle relaxing drugs on contractile responses to acetylcholine (ACh), Ba2+ and Ca2+, and on the tissue cyclic AMP levels were examined in the guinea pig ileum. Papaverine and theophylline caused a decrease both in the maximum height and the slope of dose-response curves induced by the three stimulants, and an increase in the cyclic AMP levels. Diltiazem and D-600 ...

The aim of this study was to evaluate whether dietary supplementation with an innovative silage (IS) created using 60% olive mill waste, 20% grape pomace, and deproteinised feta cheese waste solids can modulate the composition intestinal microbiota in weaned (Exp. 1) finishing 2) pigs. In Exp. 1 (40 day supplementation), forty-five crossbred pigs were randomly assigned 0% (Control), 5%, or 10% ...

This study examined whether myenteric neurons activate submucosal vasodilator pathways in in vitro combined submucosal-myenteric plexus preparations from guinea pig ileum. Exposed myenteric ganglia were electrically stimulated, and changes in the outside diameter of submucosal arterioles were monitored in adjoining tissue by videomicroscopy. Stimulation up to 18 mm from the recording site evoke...