BACKGROUND The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical. OBJECTIVES We conducted studies to evaluate rodent species sensitivity and the effects of diets varying in phytoestrogen content on the time of vaginal opening (VO) in CD-1 mice, Fischer 344 (F344) rats, and CD Sprague-Dawley (S-D) rats. METHODS Mice were weaned on p...

We investigated the relative validity of an interview-administered FFQ to estimate phytoestrogen intake among South Asian women in the UK. A population-based sample of 108 healthy South Asian women completed random repeated monthly 24-h recalls [with a subsample (n 58) also providing multiple plasma samples] over a period of 1 y followed by administration of the FFQ. The FFQ produced slightly h...

Context Studies of Phoma black stem and leaf spot disease (caused by medicaginis) in annual medics (Medicago spp.) normally involve a ‘once-only’ inoculation not reflecting multiple pathogen infection phytoestrogen production cycles the field. Phytoestrogen plants can result lower ovulation rates grazing animals. Aims We aimed to determine whether sequential infections P. medicaginis increase p...

The commentary by Boettger-Tong et al. (1) described the authors' experience with a commercially available, unidentified rodent diet with high estrogenic activity and the impact of this diet on the normal in vivo uterotropic response of ovariec-tomized 30-day-old Sprague-Dawley rats to exogenously administered estradiol. The purpose of this letter is to corroborate the authors' findings; to rep...