نتایج جستجو برای: physostigmine
تعداد نتایج: 643 فیلتر نتایج به سال:
Choline and neostigmine markedly antagonize the effect of acetylcholine (ACh) on the action potential of the venom-treated squid axon, although they themselves have no effect on conduction. Physostigmine also antagonizes the blocking action of ACh at a concentration well below that which has any effect on conduction. In contrast, d-tubocurarine (curare) increases the effect of ACh on the action...
Galanthamine, physostigmine and 9-amino-1,2,3,4-tetrahydroacridine (tacrine) were evaluated as inhibitors of human acetylcholinesterase activity from samples of postmortem human brain, fresh brain cortex biopsies and human erythrocytes. Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. The respective inhibitor con...
OBJECTIVE Lethal sepsis occurs when an excessive inflammatory response evolves that cannot be controlled by physiologic anti-inflammatory mechanisms, such as the recently described cholinergic anti-inflammatory pathway. Here we studied whether the cholinergic anti-inflammatory pathway can be activated by pharmacologic cholinesterase inhibition in vivo. DESIGN Prospective, randomized laborator...
When rats (500 g, male) are exercised on a treadmill, pretreatment with the carbamate physostigmine reduces endurance capacity (run time, RT) and increases the rate of rise of core temperature (heating rate, HR). Because physostigmine is a potential nerve agent pretreatment drug, our objective was to determine whether pharmacological intervention could reverse these decrements in performance an...
The present study examined the effects of electrolytic lesions of the Medial SeptumrVertiŽ . Ž . cal Diagonal Band of Broca MSrVDBB , the Globus Pallidus GP and the SubstantiaŽ . InnominatarVentral Pallidum SIrVP on the performance of rats in object-recognition memory and radial-maze learning tests. In the latter test, subgroups of sham-operated, MSrVDBB, SIrVP and GP rats were treated with sal...
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