Fibroblast growth factor-21 (FGF21) is a circulating hepatokine that beneficially affects carbohydrate and lipid metabolism. Here, we report that FGF21 is also an inducible, fed-state autocrine factor in adipose tissue that functions in a feed-forward loop to regulate the activity of peroxisome proliferator-activated receptor γ (PPARγ), a master transcriptional regulator of adipogenesis. FGF21 ...

Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to determine if the application of moderate hypothermia shortly after the administration of antibiotics would attenuate the inflammatory response and increase in intracranial pressure that occurs in meningitis. For this study we used a rabbi...

BACKGROUND Assessment of pulmonary edema is a key factor in monitoring and guidance of therapy in critically ill patients. To date, methods available at the bedside for estimating the physiologic correlate of pulmonary edema, extravascular lung water, often are unreliable or require invasive measurements. The aim of the present study was to develop a novel approach to reliably assess extravascu...

Assessment of weaning readiness The ability to separate successfully from mechanical ventilation is dependent upon a host of physiologic factors (Table 1). Central ventilatory drive must be adequate; the patient must be able to maintain a patent airway, if extubation or decannulation is contemplated; and the patient must be able to cough and adequately clear secretions. Airway resistance must b...

Ventriculomegaly following severe head injury (HI) is a well-noted entity, but the diagnostic criteria for labeling it as posttraumatic hydrocephalus (PTH) and the treatment protocol vary among different centers. Consequently, the reported incidence of PTH varies widely from 0.7 to 29%. If computed tomographic (CT) criteria of abnormal ventriculomegaly alone are used, the incidence of PTH is of...

R pulmonary edema (RPE) is a well-defined complication of lung re-expansion in the management of a pneumothorax or large pleural effusion. Repair of a large and longstanding traumatic diaphragmatic hernia may present a very similar physiologic situation. If the hernia is small or is promptly repaired, reduction of abdominal contents should result in lung reexpansion thus improving cardiorespira...

PATHOPHYSIOLOGY Critical care in obstetrics has many similarities in pathophysiology to the care of nonpregnant women. However, changes in the physiology of pregnant woman necessary to maintain homeostasis for both mother and fetus, especially during critical illness, result in complex pathophysiology. Understanding the normal physiologic changes during pregnancy, intrapartum, and postpartum is...

BACKGROUND Early use of continuous positive airway pressure (CPAP) has been shown to be beneficial within the setting of acute cardiogenic pulmonary edema (ACPE). The Boussignac CPAP system (BCPAP) was therefore introduced into the protocols of emergency medical services (EMS) in a large urban region. This study evaluates the implementation, practical use and complications of this prehospital t...

in order to study planting date impacts and ending season drought stress  on grain yield and  gaining weight  rate  and wheat filling period characteristics in new advanced bread wheat genotypes ,this research  is done by using plan statistical  of spilt plot  in form of complete random blocks basic  plot with 3 replications in both common separated irrigation  and ending season drought  stress...