AIM Mangiferin (Mgf), a promising therapeutic polyphenol, exhibits poor oral bioavailability. Hence, apt delivery systems are required to facilitate its gastrointestinal absorption. The requisite details on its physicochemical properties have not yet been well documented in literature. Accordingly, in order to have explicit insight into its physicochemical characteristics, the present work was ...

The concept of drug-likeness helps to optimise pharmacokinetic and pharmaceutical properties, for example, solubility, chemical stability, bioavailability and distribution profile. A number of molecular descriptors have emerged as reasonably informative and predictive, for example, the Rule-of-Five. Here, we review some current approaches, then discuss their major shortcoming, namely the static...

The present study investigated the physicochemical properties and phytochemical constituents of seed oil of Semecarpus anacardium L. to understand its biopesticidal and therapeutic potential. Preliminary phytochemical studies showed the presence of polyphenolic compounds, flavonoids, tannins, saponins, steroids in seed oil which is extracted using various organic solvents such as n-hexane, petr...

While natural products or their derivatives and mimics have contributed around 50% of current drugs, there has been no approach allowing front-loading of chemical space compliant with lead- and drug-like properties. The importance of physicochemical properties of molecules in the development of orally bioavailable drugs has been recognized. Classical natural product drug discovery has only been...

Physicochemical analysis in the microscopic sense is a critical assessment of monitoring the polymeric materials under a weathering test, and it links the accelerated laboratory test with the outdoor performance results for a long-term durability. Here, by taking an experimented example for vinyl siding after an outdoor weathering test in Okinawa, Japan for 17 years and a QUV accelerated weathe...

The aim of this study was to evaluate the physical and physicochemical properties of different brands of traditional (A, B and E), low calorie (C) and sugar-free (D) guava preserves. The results of these analysis indicated that there are differences in the physical and physicochemical properties of the different brands studied, and the partial and/or total exclusion of sugar from guava alters i...

the effect of poultry waste application on physicochemical and biological properties of sandy clay loam soil was investigated on a 7m x 7m plot of land. plot was divided into four portions and 7.5kg each of broiler, cockerel and layers waste was applied to plot a, b, and c in slurry form while plot d was used as control(no application) for eight weeks with two weeks interval. after the fourth a...

milk and dairy products are important components of a balanced diet. milk does have distinct physicochemical, biological and microbial characteristics. the bacterial contamination of milk not only reduces the nutritional quality but its consumption threatens health of the society. in this study, 100 pasteurized milk samples were collected randomly from tabriz city, northwestern and were analyze...

relative resistance of 43 iranian as well as introduced apple cultivars to blue mold (penicillium expansum) was studied within years 2010-2011. the fruit physicochemical traits were also evaluated as measures of potential resistance to decay. local p. expansum strains were isolated from decayed apple fruits and the most aggressive isolate (5,000 spores ml-1) used as inoculum. fruits were wound-...

in this project, different nettle plants from north regions of iran including tonekabon, amol and gorgan were collected. the oil was extracted using soxhlet extraction apparatus and was subjected to series of physical and chemical tests and determinations consisting of refractive index, melting point, smoke point, nonsaponifiable matter, iodine value, saponification value, peroxide value, totox...