Gene delivery vectors based on retroviral or lentiviral particles are considered powerful tools for biomedicine and biotechnology applications. Such vectors require modification at the genomic level in the form of rearrangements to allow introduction of desired genes and regulatory elements (genotypic modification) as well as engineering of the physical virus particle (phenotypic modification) ...

Efforts to improve health outcomes through behavioral modification are often complicated by external factors that may thwart success and introduce potential harm. Factors associated with traffic safety present a contemporary challenge to efforts to promote physical activity. One example is the difficulty of encouraging pedestrian-based physical activity because of the growing prevalence of dist...

We propose a modification of special relativity in which a physical energy, which may be the Planck energy, joins the speed of light as an invariant, in spite of a complete relativity of inertial frames and agreement with Einstein's theory at low energies. This is accomplished by a nonlinear modification of the action of the Lorentz group on momentum space, generated by adding a dilatation to e...

the purpose of this study is to implement a new modification of the variational iteration method (h-s-vim), which is a combination of spectral method and variational iteration method for heat transfer problems with high nonlinearity order. the merit of this method is that it does not require the solution of any linear or nonlinear system of equations unlike spectral method. furthermore the prop...

Young adult men are under-represented in health research, and little is known about how to reach and engage them in lifestyle interventions. This mixed-methods study aimed to explore young males' preferences for recruitment strategies, content, format (delivery mode and program duration and frequency), and facilitator characteristics for future physical activity and nutrition interventions. Ten...

BACKGROUND Despite the increased health risks for obese Black women, relatively little research has explored physical activity and nutrition interventions for these women. This article describes the recruitment strategies used in a program designed specifically for obese Black women. METHODS Recruitment of Black women age 30 to 65 years with body mass indices between 30 kg/m2and 50 kg/m2was c...

BACKGROUND The dramatic rise of overweight and obesity among Chinese children has greatly affected the social economic development. However, no information on the cost-effectiveness of interventions in China is available. The objective of this study is to evaluate the cost and the cost-effectiveness of a comprehensive intervention program for childhood obesity. We hypothesized the integrated in...

OBJECTIVES Children learn by observing and imitating others, meaning that their eating behaviors and physical activity may be influenced by their peers. This paper systematically reviews how preschoolers' eating behaviors and physical activity relate to their peers' behaviors, and discusses avenues for future research. METHODS Six databases were searched for quantitative, peer-reviewed studie...

Undernutrition is the single largest contributor to the global burden of disease and can be addressed through a number of highly efficacious interventions. Undernutrition generally has not received commensurate attention in policy agendas at global and national levels, however, and implementing these efficacious interventions at a national scale has proven difficult. This paper reports on the f...