Molecular imaging is a novel field in cancer research combining various in vivo imaging modalities with molecular biology. Different techniques such as magnetic resonance tomography (MRI), positron emission tomography (PET), optical imaging methods (bioluminescence, fluorescence), or combination of these are used in basic research as well as in patients in different tumor entities. In hepatobla...

As a fast developing alternative of traditional therapeutics, photodynamic therapy (PDT) is an effective, noninvasive, nontoxic therapeutics for cancer, senile macular degeneration, and so on. But the efficacy of PDT was compromised by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles (SMNPs) were strategically designed and pre...

OBJECTIVE The current study focuses on any influence that depletion of endogenous glutathione in CHO K1 cells may have on the photodynamic action of zinc phthalocyanine (ZnPc). MATERIALS AND METHODS Two lasers--a HeNe laser, 632.5 nm, maximum power output 3.5 mW, and a Toshiba semiconducting laser, 670 nm, maximum power of 7 mW--were used. Chinese Hamster Ovary cells (CHO K1) were exposed to ...

Three new Zn(ii)-, oligo- and poly(2,5-thienylene)-linked porphyrins, bearing multiple triethylene glycol (TEG) groups, on all meso aryl positions were synthesized via Stille and Suzuki coupling reactions and their photophysical properties as well as singlet oxygen generation efficiencies have been investigated to elucidate the possibility of their use as a photosensitizer for photodynamic ther...

1. Ruíz-Cendoya M, Madrid H, Pastor FJ, Mayayo E, Mariné M, Guarro J. Development of murine models of disseminated infection by Neoscytalidium dimidiatum. Med Mycol. 2010;48: 681--6. 2. Downs AM, Lear JT, Archer CB. Scytalidium hyalinum onychomycosis successfully treated with 5% amorolfine nail lacquer. Br J Dermatol. 1999;140:555. 3. Dunand J, Viguie C, Paugam A. Intermittent posaconazole regi...

In situ observations of aerosol particles remaining from evaporated cirrus crystals: Comparing clean and polluted air masses M. Seifert , J. Ström, R. Krejci , A. Minikin, A. Petzold, J.-F. Gayet, U. Schumann, and J. Ovarlez Department of Meteorology, Stockholm University, Stockholm, Sweden Air Pollution Laboratory, Institute for Applied Environmental Research, Stockholm University, Stockholm, ...

AIMS To determine the conditions of photodynamic inactivation of vesicular stomatitis virus (VSV) added to pooled coumarin plasma and the effects of the photodynamic treatment on the prothrombin times and international normalised ratio (INR) in a Netherlands national external quality assessment scheme. METHODS Pooled coumarin plasma samples were illuminated with visible light in the presence ...

In the last decade, developments in nanotechnology have provided a new field in medicine called “Nanomedicine”. Nanomedicine has provided new tools for photodynamic therapy. Quantum dots (QDs) are approximately spherical nanoparticles that have attracted broad attention and have been used in nanomedicine applications. QDs have high molar extinction coefficients and photoluminescence quantum yie...

Oral cancer is a major public health problem worldwide and is among the ten most common cancers. Despite the advances in research and treatment, oral cancer is still one of the major challenges in medical science. Common treatments for this cancer include surgery, radiotherapy, and chemotherapy, as well as adjuvant photodynamic therapy (PDT). The aim of this study was to evaluate oral cancer an...

Root canal disinfection is one of the main factors governing success of endodontic therapy. Antimicrobial photodynamic therapy (aPDT) is presented as a promising antimicrobial therapy that can eliminate microbiota present in infected root canal systems. In this study, a series of experiments investigated the effects of aPDT on cell viability and biofilm degradation ability of endopathogenic mic...