A new miniature interferometer has recently been developed for monitoring the changes of film thickness and refractive index, wherein a semiconductor laser and a photodiode detector are integrated to form a laser/detector hybrid. The laser light is collimated by a lens. When the laser light hits a film, it is reflected twice by the two interfaces between the film and the surrounding mediums. Th...

We have recently developed a wide-field photon-counting detector having high-temporal and high-spatial resolutions and capable of high-throughput (the H33D detector). Its design is based on a 25 mm diameter multi-alkali photocathode producing one photo electron per detected photon, which are then multiplied up to 107 times by a 3-microchannel plate stack. The resulting electron cloud is proximi...

In order to develop a high-resolution and high-sensitivity digital mamographic detector, to use a commercially-available and well-developed CMOS image sensor (CIS) process can be a cost-effective way. However, in any commercial CIS process, several different types of nor players can be used so that various pn-junction structures could be formed depending on the choice of nand p-layer combinatio...

A simple, specific, accurate, and stability-indicating method was developed and validated for the quantitative determination of menadione sodium bisulfite in the injectable solution formulation. The method is based on zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC) coupled with a photodiode array detector. The desired separation was achieved on the ZIC-HILIC column (250 m...

Image-guided liver biopsies can improve their success rate when combined with the optical detection of Indocyanine Green (ICG) fluorescence accumulated in tumors. Previous works used a camera coupled to thin borescope capture and quantify images from emission during procedures; however, light-scattering prevented formation sharp images, time response for weakly fluorescent tumors was very low. ...

Solid-state detector has recently been used for x-ray Computed Tomography (CT) because it has high light conversion efficiency, quantum efficiency and compact size, compared with Xenon gas detector. In order to reduce radiation dose to the patient in medical x-ray CT, it should be needed to maximize the quantum efficiency and signal-tonoise ratio (SNR) of the detector. In this study, 16-channel...

We present a system for direct parallel optical data communication between integrated circuits on neighboured printed circuit boards based on a monolithic integrated CMOS smart pixel array, fibre arrays, and VCSELs. The advantage of our system versus backplane systems is the direct data transfer through the space avoiding planar and area consuming interconnections. The detector chip allows a da...

A fast and selective ultrahigh-performance supercritical fluid chromatography photodiode array detector method was established for the qualitative and quantitative analysis of destruxins, cyclic hexadepsipeptides, from fungal culture broth samples. Prior to analysis, sample purification was carried out using an off-line solid-phase extraction protocol on a reversed-phase material in order to re...