Amide-benzothiazole based receptors act as highly selective chemosensors for Cu(ii) and Zn(ii) ions both in solution and in the solid state. Binding and crystallographic studies have been used to shed light on the mechanism of interaction between chemosensors and metal ions.

4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.

Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromBa14CO3.

Cd(II) complexes of 2-substituted benzothiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, IR, H NMR spectral data. All the Cd(II) complexes exhibit the composition [Cd(L-L)(A-A)] where L-L HPBT, MPBT and A-A, Leucine, Isoleucine, Valine. The N, O, S donor ligands and Amino acids act as a bidentate ligands...

Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles possess potent antiproliferative activity against certain cancer cells, similar to the unfluorinated 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495). In "sensitive" cancer cells, DF 203 is metabolized by, can induce expression of, and binds covalently to CYP1A1. Metabolism appears to be essential for its antiproliferative activit...