نتایج جستجو برای: phenotypic switching

تعداد نتایج: 131871  

2017
Angela Langer Adriana Moldovan Christian Harmath Susan A. Joyce David J. Clarke Ralf Heermann

Phenotypic heterogeneity in microbial communities enables genetically identical organisms to behave differently even under the same environmental conditions. Photorhabdus luminescens, a bioluminescent Gram-negative bacterium, contains a complex life cycle, which involves a symbiotic interaction with nematodes as well as a pathogenic association with insect larvae. P. luminescens exists in two d...

2017
Sara J Hanson Kevin P Byrne Kenneth H Wolfe

In haploid cells of Ogataea (Hansenula) polymorpha an environmental signal, nitrogen starvation, induces a reversible change in the structure of a chromosome. This process, mating-type switching, inverts a 19-kb DNA region to place either MATa or MATα genes under centromeric repression of transcription, depending on the orientation of the region. Here, we investigated the genetic pathway that c...

2016
Andrew C. Tadrowski Martin R. Evans Bartlomiej Waclaw

Stochastic phenotype switching has been suggested to play a beneficial role in microbial populations by leading to the division of labour among cells, or ensuring that at least some of the population survives an unexpected change in environmental conditions. Here we use a computational model to investigate an alternative possible function of stochastic phenotype switching as a way to adapt more...

2012
Philip Gerlee Sven Nelander

The brain tumour glioblastoma is characterised by diffuse and infiltrative growth into surrounding brain tissue. At the macroscopic level, the progression speed of a glioblastoma tumour is determined by two key factors: the cell proliferation rate and the cell migration speed. At the microscopic level, however, proliferation and migration appear to be mutually exclusive phenotypes, as indicated...

2014
Philipp Thomas Nikola Popović Ramon Grima

3 Slow promoter fluctuations 5 3.1 Binary promoter switching: exact solution . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.2 General solution using the conditional LNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.1 Conditional gene product distribution . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.2 Distribution of promoter states . . . . . . . . . . . ....

2017
Isabella S Kim Silja Heilmann Emily R Kansler Yan Zhang Milena Zimmer Kajan Ratnakumar Robert L Bowman Theresa Simon-Vermot Myles Fennell Ralph Garippa Liang Lu William Lee Travis Hollmann Joao B Xavier Richard M White

Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITFLO versus proliferative/MITFHI states. Since MITF also induces pigmentation, we hypothesize that macrometastatic s...

Journal: :The American journal of psychiatry 2003
Dean F MacKinnon Peter P Zandi Elliot S Gershon John I Nurnberger J Raymond DePaulo

OBJECTIVE Comorbid bipolar and panic disorders aggregate in families. A phenotypic trait shared by both disorders is the sudden shift in affect observed in panic attacks and some rapid cycling states. The authors investigated whether comorbidity of bipolar disorder and panic disorder is associated with rapid mood switching in families with a high rate of bipolar disorder. METHOD Six hundred s...

2012
David Frigola Laura Casanellas José M. Sancho Marta Ibañes

Low-copy-number molecules are involved in many functions in cells. The intrinsic fluctuations of these numbers can enable stochastic switching between multiple steady states, inducing phenotypic variability. Herein we present a theoretical and computational study based on Master Equations and Fokker-Planck and Langevin descriptions of stochastic switching for a genetic circuit of autoactivation...

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