نتایج جستجو برای: phenformin
تعداد نتایج: 275 فیلتر نتایج به سال:
IN 1918, Watanabe first demonstrated the hypoglycaemic properties of guanidine. After nearly 40 years of sporadic investigation of its derivatives, including the misadventures with synthalin (Frank, Nothmann & Wagner, 1926), this observation bore clinical fruit in the first of the biguanides, phenylethylbiguanide (phenformin) see Fig. 1). Other biguanides have since appeared including dimethylb...
Materials and Methods. Materials. Protease-inhibitor cocktail tablets and sequencing grade trypsin were obtained from Roche. N-octyl-glucoside was from Calbiochem, and tissue culture reagents were from Life Technologies. Tetracyclin-free foetal bovine sera (FBS) was from Perbio, and other tissue culture reagents were from Biowhittaker. Precast 4–12% and 10% polyacrylamide Bis-Tris gels were obt...
Phenformin's recently demonstrated efficacy in melanoma and Gleevec's demonstrated anti-proliferative action in chronic myeloid leukemia may lie within these drugs' significant pharmacokinetics, pharmacodynamics and structural homologies, which are reviewed herein. Gleevec's success in turning a fatal leukemia into a manageable chronic disease has been trumpeted in medical, economic, political ...
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