Process Analytical Technology (PAT) has been introduced as an advent of new tool which has given an opportunity for all the pharmaceutical manufacturers to improve upon their quality and compliance. The application of this technology in pharmaceutical manufacturing ensures the quality of raw material attributes that too at-line, in-line or online, which was difficult earlier, thereby decreasing...

In contrast to other EU countries, Cyprus lacks comprehensive health care coverage for its population, thus a significant portion of the population lacks insurance for medicines. Due to the small size of the country and small indigenous pharmaceutical industry, pharmaceuticals are mainly imported. Prices in the private sector are determined based on the ex-factory price from the country of orig...

OBJECTIVE To analyze the financial impact of medicine procurement with the required bioavailability and or bioequivalence tests for the basic pharmaceutical services component. METHODS A retrospective study, based on document research of competitive bidding for medicine procurement in a medium size municipality of Santa Catarina state, Southern Brazil. Bids that occurred with (2007) and witho...

This paper uses NATSEM's Pharmaceutical Benefits Model to analyse the effects of a hypothetical 25 per cent rise in patient contributions to prescribed medicines under Australia's Pharmaceutical Benefits Scheme (PBS). The model, based on microsimulation techniques, is able to provide a much broader range of outcomes information, at a much greater level of detail, than is possible with tradition...

OBJECTIVE Spending on medicines under the Pharmaceutical Benefits Scheme (PBS) represents the ninth largest expense to the Federal Government. A recent report by the Commission of Audit to the Federal Government suggested spending on the PBS is unsustainable and a capped budget, similar to New Zealand's PHARMAC model, may be required to contain costs. The objective of the present study was to c...

The circulation of substandard medicines in the developing world is a serious clinical and public health concern. Problems include under or over concentration of ingredients, contamination, poor quality ingredients, poor stability and inadequate packaging. There are multiple causes. Drugs manufactured for export are not regulated to the same standard as those for domestic use, while regulatory ...

The Specialized Pharmaceutical Services Component (CEAF) ensures the dispensing of high-cost medicines for the treatment of specific diseases. The fact that these medicines are mandatory though access is only through legal injunctions, suggests flaws in the management of pharmaceutical services. This paper analyzed adherence to Clinical Protocols and Therapeutic Guidelines (PCDT) in the dispens...

For several decades, the Fersht laboratory has been a world leader in research on protein structure and mechanism. There are pressing medical and financial needs for new medicines. Here, I use examples to illustrate how drug discovery could be more successful if it increased utilisation of approaches from the Fersht laboratory.

In order to obtain antineoplastic compounds and innovative formulations, new technologies testing methods are continuously being developed. Unfortunately, besides cancer cells, chemotherapy also affects normal cells. An option avoid toxicity is represented by the targeted treatment using novel pharmaceutical dosage forms.
 Liposomes represent a relatively form, used for their many advantag...