Here we report a spontaneous electrostatic coating of human hair with aqueous Fe3O4 colloids capable to tailor magnetic properties hair, orienting and even moving them under the influence external field. Magnetite particles were modified by cationic anionic polyelectrolytes then successfully deposited in dense arrays, starting from cuticle gaps spreading further over major surface. These biocom...

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large-scale manufacture. Current literature has primarily focused on the preparation and characterization of novel cocrystals typically containing only ...

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These processes are driven by autocrine- and paracrine-acting soluble factors (i.e., cytokines and chemokines). Proof-of-concept studies of the last decades have shown that both the deactivation and removal of hepatic MFBs ...

............................................................................................................................ 3 RESUMO .................................................................................................................................. 4 RÉSUMÉ ..............................................................................................................................

Drug delivery systems, particularly nanomaterial-based drug delivery systems, possess a tremendous amount of potential to improve diagnostic and therapeutic effects of drugs. Controlled drug delivery targeted to a specific disease is designed to significantly improve the pharmaceutical effects of drugs and reduce their side effects. Unfortunately, only a few targeted drug delivery systems can a...

190 Abstract Fragile X Syndrome (FXS) is a genetic disease due to a CGG trinucleotide expansion, named full mutation (greater than 200 CGG repeats), in the FMR1 gene locus Xq27.3; which leads to an hypermethylated region in the gene promoter therefore silencing it and lowering the expression levels of FMRP, a protein involved in synaptic plasticity and maturation. Individuals with FXS present w...

The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is to enhance the solubility, stability, safety and bioavailability of drug molecules. The purpose of this review is to discuss and summarize some of t...

Transdermal drug delivery generated major interest among large pharmaceutical companies in the 1980s and 1990s due to potential advantages of avoidance of first-pass metabolism, avoidance of exposure to the chemical and biological conditions of the gastrointestinal tract, reduction or avoidance of adverse events, improved patient compliance. Ethosome delivery system was established to develop a...

Supramolecular carriers such as micelles can be used to noncovalently bind drug molecules for pharmaceutical applications. However, these carriers can fundamentally affect diffusion-based drug transport due to host-guest coupled diffusion. We report a ternary interdiffusion study on an ionic drug in aqueous micellar solutions. Specifically, high-precision Rayleigh interferometry was used to det...

The identification of extracellular phospholipid vesicles as conveyors of cellular information has created excitement in the field of drug delivery. Biological therapeutics, including short interfering RNA and recombinant proteins, are prone to degradation, have limited ability to cross biological membranes, and may elicit immune responses. Therefore, delivery systems for such drugs are under i...