the goal of this research is preparation, optimization and in-vitro evaluation of rifampin-loaded silica nanaoparticles in order to use in pulmonary drug delivery. nanoparticles are exhaled because of thier small size, preparation of nanoaggregates in micron-sized scale and re-disrpersion of them after the deposition in the lung is one approach in order to overcome this problem, which we used i...

Abstract Optimization of Ultrasound-assisted extraction parameters is necessary to determine the optimum level parameters, including solvent-to-material ratio, power, time, solvent concentration, temperature, and pH. This review focuses on UAE parameters’ effects antioxidant activity, their interactions, best method examining activity respond UAE’s optimization. It was determined that optimal t...

Jatropha curcas seed cake is a protein-rich byproduct of oil extraction which could be used to produce protein isolates. The purpose of this study was the optimization of the protein isolation process from the seed cake of an edible provenance of J. curcas by an alkaline extraction followed by isoelectric precipitation method via a sequentially integrated optimization approach. The influence of...

The corporate challenge of being “one generation ahead” has prompted us to find new ways to improve our time to market, size, and cost of our WLAN products. By identifying the key issues which challenged us in our previous-generation products and by shifting our design effort to a platform-level optimization, we moved to a topdown approach in our Si and hardware architecture design flow. By tak...

The conditions, including mass ratio of PEG4000 to lipase, pH, and mass ratio of diatomites to lipase, for immobilization of Candida antarctica lipase with PEG non-covalent modification were optimized by means of the response surface methodology (RSM). The immobilized lipase specific activity in the reaction of transesterification was selected as the response value. A mathematical model was dev...

234 Application of Statistical Design to Optimize Culture Medium for Xylanase Production by Bacillus pumilus AB-1 Snehal Ingale, Sonam Kalyani 1 and Urvish Chhaya Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology & Allied Sciences, New Vallabh Vidyanagar-388120, Gujarat, India Natubhai V. Patel College of Pure and Applied Sciences, Vallabh Vidyanagar-388120, Gujar...

Optimization based on appropriate parameters can be applied to improve a process. Mazut degradation as a critical issue in environment requires optimization to be efficiently done. To provide biodegradation conditions, experiments were designed on the least interactions among levels of parameters consisting of pH, Tween 80, glucose, phosphorous source, nitrogen source, and time. Kinetic constan...

Cylindrocarpon destructans isolated from ginseng field was found to produce pectinolytic enzymes. A Taguchi's orthogonal array experimental design was applied to optimize the preliminary production of polygalacturonase (PG) and pectin lyase (PL) using submerged culture condition. This method was applied to evaluate the significant parameters for the production of enzymes. The process variables ...

A microwave-H2O2 process for sludge pretreatment exhibited high efficiencies of releasing organics, nitrogen, and phosphorus, but large quantities of H2O2 residues were detected. A uniform design method was thus employed in this study to further optimize H2O2 dosage by investigating effects of pH and H2O2 dosage on the amount of H2O2 residue and releases of organics, nitrogen, and phosphorus. A...

Lytic enzymes are widely used in industrial biotechnology as they are able to hydrolyze the bacterial cell wall. One application of these enzymes is the clarification of the culture broth for the production of xanthan gum, because of its viability in viscous media and high specificity. The screening process for filamentous fungi producing lytic enzymes, the optimization of production of these e...