In this review, first principles of positron emission tomography (PET) and single photon emission tomography (SPECT) are discussed together with the relative strengths and weaknesses of both techniques. With both modalities it is possible to image and, especially with PET, to measure regional tissue function, the particular function being interrogated depending on the actual tracer being used. ...

BACKGROUND Yttrium-90 (90Y) positron emission tomography with integrated computed tomography (PET/CT) represents a technological leap from 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) by coincidence imaging of low abundance internal pair production. Encouraged by favorable early experiences, we implemented post-radioembolization 90...

UNLABELLED Radioiodine therapy with (131)I is used for treatment of suspected recurrence of differentiated thyroid carcinoma. Pretherapeutic (124)I PET/CT with a low activity (~1% of (131)I activity) can be performed to determine whether uptake of (131)I, and thereby the desired therapeutic effect, may be expected. However, false-negative (124)I PET/CT results as compared with posttherapeutic (...

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Invasive surgery may be required to resect the area of seizure in approximately one third epilepsy patients. A combination diagnostic tests is used ascertain resection area, including nuclear imaging (PET/SPECT) techniques

Introduction Functional neuroimaging techniques used to study narcolepsy include single-photon emission computed tomography (SPECT), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI). SPECT shows the distribution of radioactive isotopes, the decay of which is associated with the emission of detectable single gamma photons. Examples of SPECT isotopes are techne...

BACKGROUND AND PURPOSE Patients with mild cognitive impairment (MCI) are at risk for developing Alzheimer disease (AD). To diagnose AD at an early stage, one must develop highly specific and sensitive tools to identify it among at-risk subjects. The purpose of this study was to evaluate and compare the ability of fluorodeoxyglucose-positron-emission tomography (FDG-PET), single-photon emission ...

Molecular imaging using high-resolution single-photon emission computed tomography (SPECT) and positron emission tomography (PET) has advanced elegantly and has steadily gained importance in the clinical and research arenas. Continuous efforts to integrate recent research findings for the design of different geometries and various detector technologies of SPECT and PET cameras have become the g...