The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

The desert hedgehog (Dhh) signaling pathway is involved in the development of peripheral nerves (PNs). Dhh-null mice show abnormal neuronal development and perineurial barrier function. As it was previously shown that dhh is mainly expressed in developmental nerves and Sonic hedgehog protein (dhh homologous) has therapeutic effects in neuronal survival, we attempted to investigate the possible ...

Peripheral nerve repair is still challenging for surgeons. Autologous nerve transplantation is the acknowledged therapy; however, its application is limited by the scarcity of available donor nerves, donor area morbidity, and neuroma formation. Biomaterials for engineering artificial nerves, particularly materials combined with supportive cells, display remarkable promising prospects. Schwann c...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

a common cause of peripheral nerve injury is trauma. the positive effect of antioxidants on the improvement of nerve regeneration has currently become a focus of attention. in this experiment, the effect of intraperitoneal administration of ubiquinone (coq10) on an acute experimentally sciatic nerve crush was studied in a rat model. forty-five male wistar rats, weighing between 160-180 g were u...

peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...