Vitamin D deficiency is more common in peri-menopausal women than previously thought and it may impair quality of life

Background: Abnormal uterine bleeding (AUB) is an important cause of ill health in perimenopausal women. Accurate diagnosis of the causative factor of AUB in this age group is of utmost importance so that appropriate management can be established. Objectives: The purpose of our study was to determine the diagnostic accuracy of transvaginal ultrasonography (TVS) and hysteroscopy (HYS) compared w...

Treating Vasomotor Symptoms Although 85 percent of perimenopausal women have vasomotor symptoms (hot flushes), only one half of these women find them disturbing. Twenty percent of women will experience symptoms for less than one year, but approximately 50 percent of women may experience symptoms for five years or more. Conventional estrogen therapy is effective in controlling symptoms in more t...

Recent well-controlled studies suggest that estrogen has antidepressant actions in perimenopausal women. Estrogen may also have antidepressant actions in postpartum women and across the life cycle for women who are resistant to treatment with various antidepressants. The question, however, of which depressed women to treat with antidepressants, which with estrogen, and which with both remains u...

OBJECTIVES Equol, a metabolite of the isoflavone daidzein, is hypothesized to play a major role in the health benefits of soy. We examined the effect of a new S-equol supplement on menopausal symptoms and mood states. DESIGN We conducted a randomized, double-blind, placebo-controlled trial with our new equol supplement for 12 weeks with 134 Japanese women (aged 40-59 years). They were randoml...

BACKGROUND No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in perimenopausal women. OBJECTIVE Our objective was to determine the effects of 24 wk of consumption of soy protein isolate with isoflavones (80.4 mg/d) in attenuating bone loss during the menopausal transition. DESIGN Perimenopausal subjects were randomly assigned, do...

BACKGROUND Volumes of paracardial adipose tissue (PAT) and epicardial adipose tissue (EAT) are greater after menopause. Interestingly, PAT but not EAT is associated with estradiol decline, suggesting a potential role of menopause in PAT accumulation. We assessed whether volumes of heart fat depot (EAT and PAT) were associated with coronary artery calcification (CAC) in women at midlife and whet...