We designed the study to clarify the prognostic significance of perioperative (preoperative, intraoperative, and postoperative) red blood cell (RBC) transfusion following pancreaticoduodenectomy (PD) for periampullary cancers.This study retrospectively analyzed 244 periampullary cancer patients (pancreatic cancer, 124 patients; bile duct cancer, 63 patients; and ampullary cancer, 57 patients) t...

BACKGROUND Middle-preserving pancreatectomy (MPP) is a parenchyma-sparing surgical procedure which has recently been sporadically reported for the treatment of multicentric periampullary-pancreatic lesions. However, a comprehensive recognition of this procedure has not been clearly elucidated. CASE PRESENTATION We herein report two patients undergoing MPP due to synchronous multicentric pancr...

Abstract Background Patients with a suspected early cancer affecting the periampullary region may be offered resection in form of pancreatoduodenectomy (PD) if they are suitable candidate. Whilst this offers some patients potential cure, operation is high-risk and disease recurrence common. who found to have ampullary adenocarcinoma (AA) or cholangiocarcinoma (CC) on their postoperative histolo...

PURPOSE Pancreatic cancer remains one of the most deadly cancers and carries a dismal 5-year survival rate of <5%. Therefore, there is urgent need to develop a highly accurate and minimally invasive (e.g., without instrumentation of the pancreatic duct given high rate of complications) method of detection. Our group has developed a collection of novel light-scattering technologies that provide ...

Periampullary adenocarcinoma, including pancreatic cancer, is a heterogeneous group of tumors with dismal prognosis, partially due to lack of reliable targetable and predictive biomarkers. RNA-binding motif protein 3 (RBM3) has previously been shown to be an independent prognostic and predictive biomarker in several types of cancer. Herein, we examined the prognostic value of RBM3 in periampull...

CONTEXT There is limited information available about the feasibility and benefits of synchronous resection of liver metastases in patients with pancreatic and periampullary cancer undergoing pancreaticoduodenectomy. OBJECTIVE We report on our experience with 7 such patients. DESIGN Analysis of the prospective database was carried out to identify patients who underwent synchronous resection ...

Introduction: Periampullary diverticula (PD) are generally asymptomatic and frequently diagnosed coincidentally during endoscopic retrograde cholangiopancreatography (ERCP). Aim: To investigate the impact of PD on procedural success in ERCP for common bile duct (CBD) stones, and possible complications. Material and methods: Five hundred and eighty-six patients diagnosed with CBD stones by diagn...

BACKGROUND A recent Cochrane Review found that preoperative biliary drainage (PBD) in patients with resectable pancreatic and periampullary cancer undergoing surgery for obstructive jaundice is associated with similar mortality but increased serious morbidity compared with no PBD. Despite this clinical evidence of its lack of effectiveness, PBD is still in use. We considered the economic implic...

CONTEXT Pancreaticoduodenectomy is the procedure of choice for resectable cancer of the periampullary region. These tumors account for 4% of deaths from cancer, being referred to as one of the lowest survival rates at 5 years. Surgery remains a complex procedure with substantial morbidity and mortality. Despite reports of up to 30% mortality rates, in centers of excellence it have been identifi...