Synthesis of S peptides......................................................................................................................... 4 WT-S peptide – 8 ................................................................................................................................ 5 OX-S-Cys peptide – 2c ...................................................................................

Peptoids are a diverse family of sequence-defined oligomers N-substituted glycine monomers, that can be readily accessed by the solid-phase submonomer synthesis method. Due to versatility and efficiency this chemistry, easy access hundreds potential there is an enormous sequence space explored. This has enabled researchers from many different fields custom-design peptoid sequences tailored wide...

abstract background antibiotic resistance makes antimicrobial peptides (amps) agents an alternative for treatment of pathogenic diseases. they are isolated from various animals invertebrates, vertebrates and plants. the present study shows the electrophoretic pattern of protein and peptides from vicia faba seed and reports our first attempt to study the antibacterial activity of vicia faba seed...

The in silico modelling of peptides complementary to lactoferrin was carried out using the Protein 3D software package and replication natural bonding site between pneumococcal surface protein (PSP) (LF). modeling based on analysis conjugated ion–hydrogen bond systems these proteins (CIHBS). oligopeptide EEVAPQAQAKIAELENQVHRLE proposed via computer synthesized solid phase synthesis technique, p...

Here we report a simple procedure for generating colorimetric histone deacetylase (HDAC) substrates by solid-phase peptide synthesis based on racemization-free couplings of amino acid chlorides. We demonstrate the applicability of these substrates in HDAC assays.

The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveni...

The N-terminal 25 residue segment of human surfactant protein B (SP-B(1-25)) was synthesised in 26% yield by manual Fmoc solid-phase peptide synthesis (Fmoc SPPS) using low-loading Fmoc-Gly-Wang resin. Substantial oxidation of Met(21) occurred during the synthesis, and the addition of Bu(4)NBr to a TFA/water/EDT/TIS cleavage cocktail enabled facile reduction of Met(O)(21)-SP-B(1-25) to SP-B(1-2...

The site(s) of action of a bovine pituitary diabetogenic peptide that produces hyperglycemia and hyperinsulinemia in vivo (dogs or humans) was investigated in vitro. When rat diaphragms were incubated with the peptide in the presence of insulin, the peptide depressed insulin-mediated (a) glucose uptake, (b) glycogen synthesis, and (c) glycogen synthase activation (conversion of D to I form). In...