1. Re-establishment of renal blood flow after total renal ischaemia of 4 h duration causes a pressor response in pentobarbitone anaesthetized rats and cats.2. The pressor response is related to the release of renin from the ischaemic kidney.3. Spinal section at any cervical level or stellate ganglionectomy abolishes the pressor response but spinal section caudad to the thorax or vagotomy and tr...

Preganglionic cervical and splanchnic sympathetic activity was recorded before and during administration of inhalation anaesthetics, in rabbits ventilated with oxygen and given gallamine. During control periods, when light anaesthesia was maintained with pentobarbitone, sympathetic discharge responded to changes in arterial pressure. Increased arterial Pco3 exaggerated the amplitude of the resp...

The ethanol extract of Cyperus rotundus (EECR) was tested for possible pharmacological effects on experimental animals. EECR significantly potentiated the sleeping time of mice induced by standard hypnotics, viz. pentobarbitone sodium, diazepam, and meprobamate in a dose dependent manner. EECR showed significant analgesic properties as evidenced by the significant reduction in the number of wri...

Cardiac arrhythmias and cardiac arrest were induced in pentobarbitone anaesthetised cats by slow intravenous infusion of ouabain. The dose of ouabain required for the induction of the stages of arrhythmias and cardiac arrest and the maximum pressor effect induced by ouabain were assessed in control and clonidine pretreated cats. Clonidine caused significant delay in the onset of cardiotonic eff...