Seventy-nine patients with cutaneous leishmaniasis were included in this study. The experimental group (n = 38) was treated with pentamidine isothionate in a dose of 4mg/kg/day on alternate days, for one week. The control group (n = 41) was treated with N-methylglucamine in a dose of 20mgSbV/kg/day for 20 days. Twenty-one isolates were identified using monoclonal antibody technique. We characte...

This review describes the pharmacokinetic properties of the systemically administered antileishmanial drugs pentavalent antimony, paromomycin, pentamidine, miltefosine and amphotericin B (AMB), including their absorption, distribution, metabolism and excretion and potential drug-drug interactions. This overview provides an understanding of their clinical pharmacokinetics, which could assist in ...

Case Report (Dr R F Miller) The patient was a 39 year old male homosexual book publisher. He first presented to this hospital in December 1988 with a diagnosis of oral hairy leukoplakia and at the time was found to be HIV 1 antibody positive and to be hepatitis B immune. Not long after this he developed a cough, increasing exertional dyspnoea and a reduced exercise tolerance. He was admitted fo...

Although early stages of clear cell renal cell carcinoma (ccRCC) are curable, survival outcome for metastatic ccRCC remains poor. We previously established a highly accurate signature of differentially expressed genes that distinguish ccRCC from normal kidney. The purpose of this study was to apply a new individualized bioinformatics analysis (IBA) strategy to these transcriptome data in conjun...

Since Thrower and Valentine (1943) observed the trypanocidal and bacteriostatic action of propamidine, a number of investigators have studied the antimicrobial action of the aromatic diamidines. Kohn (1943) reported the inhibition of growth of Escherichia coli and Staphylococcus aureus by propamidine. This observation was extended to include Lactobacillus casei and Streptococcus lactis strain R...