Relatively few studies have been made on the lipide metabolism of Penicillium chrysogenum, although large quantities of these compounds are used as antifoam agents in the production of penicillin. Goldschmidt and Koffler (1) demonstrated that unsaturated long chain fatty acids present in the antifoam were responsible for stimulation of penicillin yields, since many physiologically inert compoun...

In this study we developed a new method for accurately determining the pentose phosphate pathway (PPP) split ratio, an important metabolic parameter in the primary metabolism of a cell. This method is based on simultaneous feeding of unlabeled glucose and trace amounts of [U-C]gluconate, followed by measurement of the mass isotopomers of the intracellular metabolites surrounding the 6-phosphogl...

The biosynthesis of penicillin by strains Penicillium chrysogenum requires a supply of of the amino acids valine, cysteine and a-aminoadipic acid1}. a-Aminoadipic acid has received most attention since it is an intermediate of lysine biosynthesis in fungi2) and therefore forms a branch point between lysine and penicillin biosynthesis in P. chrysogenumz~6). Higher producing strains of P. chrysog...

The important developments in industrial fermentation lead to the utilization of microbial enzymes in different applications. Selected organisms Aspergillus fumigatus, A. terreus, Penicillium chrysogenum, P. funiculosum and Fusarium moniliforme. Various environmental parameters like pH, temperature and nutritional parameters such as carbon and nitrogen sources were investigated to optimize the ...