In this work, we present a pen-based user interface (UI) that makes manual geometry decomposition easier and helps reduce user time spent on geometry decomposition for hexahedral meshing. This paper presents the first attempt to apply a pen-based UI for geometry preparation for mesh generation. The proposed UI is more natural, intuitive, and easier to use than existing interfaces such as Window...

A hydrogel pen consisting of a microscopic pyramid containing an electrolyte offers a localized electroactive area on the nanometer scale via controlled contact of the apex with a working electrode. The hydrogel pen merges the fine control of atomic force microscopy with non-linear diffusion of an ultramicroelectrode, producing a faradaic current that depends on the small electroactive area. Th...

Flagellin protein was isolated and purified from two serotype reference strains of Campylobacter jejuni, Pen 1 and Pen 3. Each preparation was shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to consist of a diffuse band with a molecular mass of approximately 62 kilodaltons. Antisera were prepared against flagellin from Pen 1, and specific antibody was isolated by affinity chr...

UNLABELLED Previous research has reported that ease of use of and preference for a delivery device are associated with greater patient compliance - an important factor in achieving optimal therapeutic results. The objective of this study was to assess the ease-of-use of a new disposable pen (GoQuick(®), Pfizer, Inc.) versus the current reusable pen (GENOTROPIN Pen(®), Pfizer, Inc.) to inject a ...

PURPOSE This multicenter, randomized, crossover study compared preference, ease of use, acceptability, satisfaction, and safety of repeated subcutaneous (SC) self-administrations with prefilled pens and prefilled syringes delivering methotrexate (MTX), in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS The study (ClinicalTrials.gov number NCT01793259) enrolled 120 patients requi...

In hand-sketched drawings, nearly identical strokes may have different meanings to a user. For instance, a scribble could signify either that a shape should be filled in or that it should be deleted. This work describes a method for determining user intention in drawing scribbles in the context of a pen-based computer sketch. Our study shows that given two strokes, a circle and a scribble, two ...

The ability of the lesser mealworm, Alphitobius diaperinus (Panzer), commonly known as the darkling beetle, to transmit marker Salmonella Typhimurium to day-of-hatch broiler chicks was evaluated, as well as the spread to nonchallenged pen mates. In trial 1, day-of-hatch chicks were orally gavaged with 4 larval or 4 adult beetles that had been exposed to marker Salmonella-inoculated feed for 72 ...

This paper describes a Markov random field (MRF) model with weighting parameters optimized by conditional random field (CRF) for on-line recognition of handwritten Japanese characters. The model extracts feature points along the pen-tip trace from pen-down to pen-up and sets each feature point from an input pattern as a site and each state from a character class as a label. It employs the coord...

BACKGROUND Cervical disc disease is a common and occasionally disabling condition, occurring as a natural consequence of aging in the vast majority of the adult population. Percutaneous epidural neuroplasty (PEN) has been used to deliver highly concentrated drugs for chronic neck pain and to prevent scarring in cases refractory to conventional epidural blocks. However, the clinical course after...

This study aimed to investigate and compare nonlinear growth models (NLMs) with the predicted performance of broilers using an artificial neural network (ANN). Six hundred forty broiler chicks were sexed and randomly reared in 32 separate pens as a factorial experiment with 4 treatments and 4 replicates including 20 birds per pen in a 42-day period. Treatments consisted of 2 metabolic energy le...