Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that initially manifests in the form of intraoral lesions, which spread to other mucous membranes and the skin. The etiology of pemphigus vulgaris is still unknown, although the disease has attracted considerable interest. The pemphigus group of diseases is characterized by the production of autoantibodies against intercellular su...

BACKGROUND Drug-specific CD8+ TH1 lymphocytes have been found in the peripheral blood and involved skin of patients with drug-induced bullous exanthems. OBJECTIVES To determine whether the interferon-gamma release test can identify culprit drugs in pemphigus patients. METHODS Clinical and laboratory workup for pemphigus was performed in 14 pemphigus vulgaris patients who had been exposed to...

psoriasis and pemphigus vulgaris are two inflammatory and autoimmune diseases. their concomitant occurrence in one patient is very rare. we describe a 57-year-old patient with a history of severe plaque type psoriasis for 2 years. after a few months, he presented with disseminated bullae and mucosal erosions which were documented as pemphigus vulgaris. both of the diseases were successfully con...

objectives: regarding the implication of viruses particularly herpes in pemphigus vulgaris, we sought to assess and compare the level of immunoglobulin g (igg) antibodies against herpes simplex virus types 1 and 2 (hsv1 and hsv2), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with pemphigus vulgaris and healthy people.     materials and methods: in this cross-sectional study, 2...

Pemphigus is a group of autoimmune blistering disorders characterized by blister formation that is caused by loss of keratinocyte cell-to-cell adhesion in the epidermis due to circulating autoantibodies against desmosomal proteins [1]. The disease is extremely rare in pediatric age group. Pemphigus vulgaris (PV) is the most common form seen in children, as seen in adults. Although prevalence of...

First described as a distint clinical entity in 1994, IgG/IgA pemphigus is a rare type of atypical pemphigus with a variety of clinical, histological, and immunological manifestations. Only 21 cases of this disease have been reported in the literature to date. We report a case of IgG/IgA pemphigus in a 54-year old female in which the diagnosis was delayed due to negative direct immunofluorescen...

Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically characterized by scaly and crusty cutaneous erosions involving the seborrheic areas. The patient can eventually become erythrodermic. There are reports of atypical cases of pemphigus foliaceus with pustules and neutrophils, and clinical differentiation from generalized pustular psoriasis of von Zumbusch is difficult. We...

Increased incidences of Kaposi's sarcoma and lymphoid malignancies have been observed in patients with pemphigus, and the human herpesvirus 8 (HHV-8) is very strongly associated with these tumors. Because the virus may be one of the triggering factors of pemphigus, we undertook this study to screen for the presence of HHV-8 in chronic blistering skin diseases including pemphigus. A total of 45 ...

Yoshimura et al. set out to characterize the clinical and immuno logical profiles of patients with drug-induced pemphigus. They studied 17 Japanese patients with druginduced pemphigus diagnosed between 1997 and 2012. They recorded clinical and histopathological manifestations, responsible drugs, immunofluorescence findings, enzymelinked immunosorbent assay (ELISA) and immunoblotting (IB) result...

Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was co...