The objective of this work is to investigate the thermodynamic and scattering behavior of tetra-poly(ethylene glycol) (PEG) gels. Complementary measurements, including osmotic swelling pressure, elastic modulus, and small angle neutron scattering (SANS), are reported for a series of tetra-PEG gels made from different molecular weight precursor chains at different concentrations. Analysis of the...

Crosslinked poly(ethylene oxide) or glycol) (PEG) is an ideal membrane material for separation of CO2 from light gases (e.g., H2, N2, O2, CH4 etc). In these membranes, crosslinking used as a tool to suppress crystallinity the PEG segments. spite extensive effort develop crosslinked membranes in last two decades, it remains challenge establish structure–property relationships. This paper points ...

To understand the physics of polymer equilibrium and dynamics in the confines of ion channel pores, we study partitioning of poly(ethylene glycol)s (PEGs) of different molecular weights into the bacterial porin, OmpF. Thermodynamic and kinetic parameters of partitioning are deduced from the effects of polymer addition on ion currents through single OmpF channels reconstituted into planar lipid ...

Water-soluble polymers such as polyethylene glycol (PEG) are critical components of industrial processes ranging from drug delivery to water purification. However, the understanding of the microscopic structure of these polymers in water and of the thermodynamics of the mixtures is limited because available experimental techniques (such as SLS and SANS) give little information about conformatio...

The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and controlled by the three-dimensional structure. In addition, a number of these hydrogel carriers are mucoadhesive and can be used for prot...

The aim of this study was to prepare poly-DL-lactide/polyethylene glycol (PDLLA/PEG) blends to improve medium absorption and cell proliferation in the three-dimensional (3-D) structure of their scaffolds. Carbon dioxide (CO2) was used as a foaming agent to create porosity in these blends. The results of Fourier transform infrared (FTIR) spectroscopy demonstrated that the blends were homogeneous...

Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties vivo for diverse biomedical applications. Previous studies have examined the effect of PEG molecular weight coating density on biological fate various particles; however, there are few that detail fundamental role architecture engineering bio–nano interactions. Herein, we engin...

Cellulosic bottlebrushes with polystyrene (PS) and poly(ethylene glycol) (PEG) side chains at the O-6 O-2,3 positions, respectively (PEG-PS-cellulose), were synthesized characterized in diluted solution to reveal second structure of heterografted bottlebrushes. The regioselectivity degree substitution evaluated by 1H- 13C-nuclear magnetic resonance spectroscopy size-exclusion chromatography (SE...

Apoptosis is a form of programmed cell death characterized by cytoplasmic condensation, plasma membrane blebbing and nuclear pycnosis, leading to nuclear DNA breakdown into multiples of ∼200 bp oligonucleosomal size fragments. The detection of apoptosis in cultured cells relies heavily on techniques involving the extraction of nuclear DNA and characterization of such oligonucleosomal ladders by...

This work aimed to develop a subcutaneous implant for prolonged delivery of LEVO treat hypothyroidism. could overcome challenges with patient compliance and co-administration improve treatment this condition. For purpose, implants were produced by solvent casting mixtures poly(caprolactone) (PCL), poly(ethylene glycol) (PEG) sodium. These contained PCL differing molecular weight, PEG different ...