نتایج جستجو برای: pediatric tumors
تعداد نتایج: 289406 فیلتر نتایج به سال:
Abstract Pediatric low-grade glioma incidence has been rising in the U.S. over last 20 years, concurrent with a rate of obesity both adult and pediatric populations. Recently, children obese mothers have demonstrated to increased rates several tumors, including brain tumors. Importantly, is driven large part by diet, given abundance accessibility high-fat, high-sugar food choices. High-fat diet...
BACKGROUND AND PURPOSE The pattern of contrast leakage from DSC tissue signal intensity time curves have shown utility in distinguishing adult brain neoplasms, but has limited description in the literature for pediatric brain tumors. The purpose of this study is to evaluate the utility of grading pediatric brain tumors with this technique. MATERIALS AND METHODS A retrospective review of tissu...
BACKGROUND Primitive brain tumors are the leading cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pediatric brain tumors and are of clinical relevance remains to be determined. METHODOLOGY/PRINCIP...
Malignant germ cell tumors (GCT) of childhood are rare and heterogeneous neoplasms thought to arise from primordial germ cells. They vary substantially in their natural history and show important clinical differences from their adult counterparts. To address the biological basis for these observations, we have undertaken a comprehensive analysis of global gene expression patterns in pediatric m...
Background: Brain tumors in the cerebellum site, especially in the cranial nuclei, are most commonly associated with cognitive impairment in children, but the differences in dimensions of cognitive impairments in pediatric benign and malignant tumors are rarely studied. Meanwhile, cognitive impairments in this area are required to be widely studied. This study aimed at using Computerized Addenb...
giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female pati...
Astrocytomas are the most common pediatric brain tumors, accounting for 7%–8% of all childhood cancers. Relatively few studies have been performed on their molecular properties; therefore, classification of pediatric astrocytic tumors into genetic subtypes similar to that of adult tumors remains to be defined. Here, we report an extensive characterization of 44 pediatric astrocytomas—16 diffuse...
Introduction: According to the results of studies from different parts of the world, malignancies in children are rare. Despite this fact, malignant neoplasms remain the second leading cause of death in children after accidents. ALL, CNS tumors and lymphomas are the most common malignancies in children. They account for approximately more than 50% of malignancies and occur more frequently in b...
BACKGROUND The PI3K/AKT/mTOR pathway is aberrantly activated in many pediatric solid tumors including gliomas and medulloblastomas. Preclinical data in a pediatric glioma model demonstrated that the combination of perifosine (AKT inhibitor) and temsirolimus (mTOR inhibitor) is more potent at inhibiting the axis than either agent alone. We conducted this study to assess pharmacokinetics and iden...
Introduction: Primary cardiac tumors are extremely rare in infants and children . Most primary cardiac tumors in pediatric age group are benign, and less than 10% of such tumors are malignant. Many of these tumors are asymptomatic and incidentally diagnosed. The clinical manifestations are very different and includes direct cardiac effect, systemic effect , and embolic phenomena. Every infant...
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