RATIONALE Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence of LEP in systemic lupus erythematosus (SLE) ranges from 2% to 5%. In the previous literature, most LEP patients were women aged from 20 to 60 years, while pediatric cases were rare, all of whom appeared on their own without SLE.A rare LEP in a 10-year-old female child with severe SLE is pres...

Methods Analytic descriptive study. 89 patients with diagnosis SLE (1986 ACR criteria) from a rheumatology center at a pediatric hospital were evaluated at the time of diagnosis and twelve months after. Medical records were reviewed registering the following variables: score SLEDAI, Antinuclear antibodies (ANAs), Anti-DNA antibodies and complement C3 and C4 levels. Analysis was done through par...

Cardiovascular morbidity and mortality are becoming major health concerns for adults with inflammatory rheumatic diseases. The enhanced atherogenesis in this patient population is promoted by the exposure to traditional risk factors as well as nontraditional cardiovascular insults, such as corticosteroid therapy, chronic inflammation and autoantibodies. Despite definite differences between many...

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems, and is characterized by the deposition of immune complexes and a large array of autoantibodies. Thrombosis is a relatively frequent and serious complication of SLE; however, renal infarction in young patients with antiphospholipid antibody-negative lupus has rarely been reported, and no pediatric case ...

3. SOLOMAN DH, KAVANAUGH AJ, SCHUR PH: American College of Rheumatology Ad Hoc Committee on Immunologic Testing: Evidence-based guidelines for the use of Immunologic tests: antinuclear antibody testing. Arthritis Rheum 2002; 47: 434-44. 4. GORDON T. ISENBURG D: The Endocrinologic Associations ofthe Autoimmune Rheumatic Diseases. Semin Arthritis Rheum 1987; 17: 58-70. 5. TEKTONIDOU MG, ANAPLIOUT...

background & objectives: chronicity of lupus nephritis (ln) should be considered for interaction of cell mediated immunity (cmi) and dendritic cells in glomeruli and tubulointerstitial areas. in this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. materials & m...

Background: Systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. The importance of some genes in the development of systemic lupus erythematosus has been implicated. The gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has ...

Essential generalized telangiectasia as the result of postcapillary venule dilatation, is characterized by the sudden development of generalized telangiectasias, sometimes involving the conjunctiva. A few pediatric cases have been reported. The main condition in the differential diagnosis includes syndromes with telangiectasia such as hereditary hemorrhagic telangiectasia of Rendu-Osler, unilat...

mysterious illness, eventually diagnosed as acute renal failure secondary to lupus. Although she had hardly been sick a day in her life, she now was dead, which was a truly devastating loss for our entire family. In the process, I learned that one does not progress neatly through, or ever quite recover from, the so-called stages of grief, but simply tries to outlast them and create meaning wher...

Purpose Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies directed against many highly-conserved nuclear antigens. 15% of SLE patients develop disease in childhood or adolescence, and pediatric (pSLE) patients often have more severe disease onset and organ system involvement. Antigen microarray technology allows the comprehensive analysis of autoantibodies ...