نتایج جستجو برای: pediatric brain tumors

تعداد نتایج: 736812  

Journal: :Science translational medicine 2017
Sharareh Gholamin Siddhartha S Mitra Abdullah H Feroze Jie Liu Suzana A Kahn Michael Zhang Rogelio Esparza Chase Richard Vijay Ramaswamy Marc Remke Anne K Volkmer Stephen Willingham Anitha Ponnuswami Aaron McCarty Patricia Lovelace Theresa A Storm Simone Schubert Gregor Hutter Cyndhavi Narayanan Pauline Chu Eric H Raabe Griffith Harsh Michael D Taylor Michelle Monje Yoon-Jae Cho Ravi Majeti Jens P Volkmer Paul G Fisher Gerald Grant Gary K Steinberg Hannes Vogel Michael Edwards Irving L Weissman Samuel H Cheshier

Morbidity and mortality associated with pediatric malignant primary brain tumors remain high in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via blockade of the anti-phagocytic CD47-SIRPα interaction using anti-CD47 antibodies has shown promise in preclinical xenografts of various human malignancies. We demonstrate the effect of a humanized anti-CD47 antib...

Journal: :Proceedings of the National Academy of Sciences 2003

Journal: :International Journal of Radiation Oncology*Biology*Physics 2020

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