lactoferrin (lf) is a bioactive protein present in all external secretions such as milk that plays important role in the innate host defense. therefore, the lf has a major role in bovine mammary gland defense during mastitis. in this study, 5’-flanking region of bovine lf gene containing three single nucleotide polymorphisms (snps) at positions −602 (t/g), −600 (a/g) and -586 (t/c) were screene...

The mossy fiber (MF) pathway is critical to hippocampal function and influenced by gonadal hormones. Physiological data are limited, so we asked whether basal transmission and long-term potentiation (LTP) differed in slices of adult male and female rats. The results showed small sex differences in basal transmission but striking sex differences in opioid receptor sensitivity and LTP. When slice...

1. Physical training has been proposed to increase vagal control of heart rate in chronic heart failure. We studied the effects of physical training on cardiovascular control in 6 moderate to severe heart failure (NYHA II-III) patients and 6 age matched normal controls in a randomized controlled cross over trial (Training vs Detraining). 2. Five weeks training (20 min/day, 5 days/week bicycle e...

Materials and methods. 51 patients, who were ill with generalized peritonitis, went through a prospective randomized research. They were randomized on groups depending on the objective score SAPS (1984): 29 survived people (53%) and 22 people with favorable end (47%). Intensive care and surgical tactics standardized patients. Lactoferrin (LF) as modulator of systemic inflammatory response (SIR)...

A "Qi" feeling (a kind of comfortable sense) during and after acupuncture is one of the important determinants to decide quantity (trial number) of acupuncture stimulation. It has been reported that various autonomic responses were evoked when patients felt "Qi" and when acupuncture stimulation had significant effects on EEGs. However, quantitative relationships among acupuncture stimulation, E...

A "Qi" feeling (a kind of comfortable sense) during and after acupuncture is one of the important determinants to decide quantity (trial number) of acupuncture stimulation. It has been reported that various autonomic responses were evoked when patients felt "Qi" and when acupuncture stimulation had significant effects on EEGs. However, quantitative relationships among acupuncture stimulation, E...

Human papillomavirus (HPV) cause common warts, laryngeal papilloma and genital condylomata and might lead to development of cervical cancer. Lactoferrin (LF) is a member of the transferrin family, which has antiviral activity against HPV-16. LF is an important player in the defense against pathogenic microorganisms and has also been shown to have activity against several viruses including herpe...

Lethal factor (LF), a zinc-dependent protease of high specificity produced by Bacillus anthracis, is the effector component of the binary toxin that causes death in anthrax. New therapeutics targeting the toxin are required to reduce systemic anthrax-related fatalities. In particular, new insights into the LF catalytic mechanism will be useful for the development of LF inhibitors. We evaluated ...

Anthrax lethal factor (LF) is a Zn(+2)-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF (LF-HMA) which differs from wild type LF (LF-A) by the addition of two residues (His-Met) to the native Ala (A) terminus as a result of cloning manipulations has 3-fold lower potency toward culture...

STUDY DESIGN Cross-sectional study. PURPOSE To investigate the relationship between ligamentum flavum (LF) thickening and lumbar segmental instability and disc degeneration and facet joint osteoarthritis. OVERVIEW OF LITERATURE Posterior spinal structures, including LF thickness, play a major role in lumbar spinal canal stenosis pathogenesis. The cause of LF thickening is multifactorial and...