نتایج جستجو برای: pdz domain

تعداد نتایج: 406848  

2000
Nils B. Adey Liwen Huang Patricia A. Ormonde Michelle L. Baumgard Ralph Pero Deepthi V. Byreddy Sean V. Tavtigian Paul L. Bartel

Two-hybrid searches with the tumor suppressor MMAC1/PTEN isolated the proteins hDLG and hMAST205. Further two-hybrid analysis and microtiter plate binding assays localized the sites of interaction to PDZ domains from hDLG and hMAST205 and the PDZ binding domain at the COOH terminus of MMAC1/PTEN. A synthetic peptide derived from the MMAC1/PTEN PDZ binding domain (MMAC1/PTEN-PDZBD) was used to c...

Journal: :Molecular cell 2012
Yong Chen Ren Sheng Morten Källberg Antonina Silkov Moe P Tun Nitin Bhardwaj Svetlana Kurilova Randy A Hall Barry Honig Hui Lu Wonhwa Cho

Emerging evidence indicates that membrane lipids regulate protein networking by directly interacting with protein-interaction domains (PIDs). As a pilot study to identify and functionally annodate lipid-binding PIDs on a genomic scale, we performed experimental and computational studies of PDZ domains. Characterization of 70 PDZ domains showed that ~40% had submicromolar membrane affinity. Usin...

Journal: :Learning & memory 2006
Jannic Boehm Ingrid Ehrlich Helen Hsieh Roberto Malinow

The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and ...

Journal: :Molecular & cellular proteomics : MCP 2008
Serge M Gisler Saranya Kittanakom Daniel Fuster Victoria Wong Mia Bertic Tamara Radanovic Randy A Hall Heini Murer Jürg Biber Daniel Markovich Orson W Moe Igor Stagljar

PDZ-binding motifs are found in the C-terminal tails of numerous integral membrane proteins where they mediate specific protein-protein interactions by binding to PDZ-containing proteins. Conventional yeast two-hybrid screens have been used to probe protein-protein interactions of these soluble C termini. However, to date no in vivo technology has been available to study interactions between th...

Journal: :Molecular and cellular biology 2001
K Jo B Rutten R C Bunn D S Bredt

The actinin-associated LIM protein, ALP, is the prototype of a large family of proteins containing an N-terminal PDZ domain and a C-terminal LIM domain. These PDZ-LIM proteins are components of the muscle cytoskeleton and occur along the Z lines owing to interaction of the PDZ domain with the spectrin-like repeats of alpha-actinin. Because PDZ and LIM domains are typically found in proteins tha...

Journal: :The Journal of biological chemistry 2006
Brent A Appleton Yingnan Zhang Ping Wu Jian Ping Yin Walter Hunziker Nicholas J Skelton Sachdev S Sidhu Christian Wiesmann

We report a structural comparison of the first PDZ domain of ZO-1 (ZO1-PDZ1) and the PDZ domain of Erbin (Erbin-PDZ). Although the binding profile of Erbin-PDZ is extremely specific ([D/E][T/S]WV(COOH)), that of ZO1-PDZ1 is similar ([R/K/S/T][T/S][W/Y][V/I/L](COOH)) but broadened by increased promiscuity for three of the last four ligand residues. Consequently, the biological function of ZO-1 i...

Journal: :Acta crystallographica. Section D, Biological crystallography 2002
Seong Ho Park Young Jun Im Seong Hwan Rho Jun Hyuck Lee Soyoung Yang Eunjoon Kim Soo Hyun Eom

Shank proteins are a new family of scaffold proteins interacting with various membrane and cytoplasmic proteins. Shank contains multiple protein-protein interaction sites, including ankyrin repeats, an SH3 domain, a PDZ domain, a long proline-rich region and an SAM domain. The PDZ domain of Shank binds to the C-terminus of guanylate kinase-associated protein (GKAP). The PDZ domain of Shank1 fro...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Antonella Piccini Roberto Malinow

Interactions between AMPA receptor subunits and proteins containing postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domains have been shown to play critical roles in the proper trafficking of receptors to excitatory synapses. Synaptic accumulation of AMPA receptors containing the glutamate receptor 1 (GluR1) subunit can be driven by calcium/calmodulin-dependent protein kinase II act...

2016
Ahmed Aljameeli Arvind Thakkar Shibu Thomas Vijaybasker Lakshmikanthan Kenneth A. Iczkowski Girish V. Shah

The role of neuroendocrine peptide calcitonin (CT) and its receptor (CTR) in epithelial cancer progression is an emerging concept with great clinical potential. Expression of CT and CTR is frequently elevated in prostate cancers (PCs) and activation of CT-CTR axis in non-invasive PC cells induces an invasive phenotype. Here we show by yeast-two hybrid screens that CTR associates with the tight ...

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