نتایج جستجو برای: pc3
تعداد نتایج: 2157 فیلتر نتایج به سال:
Background & Aim: Prostate cancer (PCa) is one of the most common cancers of the male urinary system and is also the second leading cause of cancer deaths in men. In the present study, the effects of Stichodactyla haddoni on the viability of prostate cancer cells (PC3) were investigated. Methods: In the semi experimental study, sea anemones were sampled at random using an identification key. T...
The treatment of prostate cancer patients usually starts with androgen ablation and followed by chemotherapy; however, in some cases the tumor develops resistant phenotype. Combination therapy is currently regarded as a cornerstone in cancer therapy to overcome the drug resistance. Herein, we investigated the combinatory effect of Docetaxel and Trastuzumab with a novel nanomedicine, BCc1. Also,...
BACKGROUND Tumors commonly outgrow their blood supply, thereby creating hypoxic conditions, which induce apoptosis and increase expression of angiogenic growth factors. The bcl-2 oncogene inhibits apoptosis induced by a variety of stimuli, including hypoxia. On the basis of bcl-2's role in regulating apoptosis in response to hypoxia, we hypothesized that this oncogene might affect other respons...
The database PubChem was classified using 42 integer value descriptors of molecular structure, here called molecular quantum numbers (MQNs), which count atoms and bond types, polar groups, and topological features. Principal component analysis of the MQN data set shows that PubChem compounds occupy a partially filled elliptical cone in the (PC1,PC2,PC3) space whose axis is the first principal c...
Introduction: Defects in PTEN gene play an important role in the initiation of the prostate cancer. MAGI2 is recognized as a frame which assists in stabilizing PTEN protein and enhances its tumor suppressor function. As miR-101 down-regulates MAGI2 expression, it can indirectly cause to reduce the PTEN activity. Methods:LnCap, PC3 and DU-145 prostate cancer cell lines were studied in order to ...
سرطان دومین عامل مرگ در سراسر جهان میباشد. روشهای درمان این بیماری اغلب ناکارا بوده و علیرغم وجود روشهای درمانی موجود، همچنان نیاز به تحقیق برای کشف روشهای جدید و هدفمند برای درمان این بیماری احساس میشود. هدف از این پژوهش، سنتز منوترپنوئیدی بهنام فنچیل-3و4دیمتوکسی بنزوات (FDB) از طریق انجام واکنش استریفیکاسیون بین فنچیل- 3و4- دیمتوکسی بنزوات و بررسی اثرات سمیت سلولی و ضدسرطانی این ...
Aim: Acquired docetaxel (DOC) resistance of prostate cancer (PCa) is still a clinical problem. In addition to failure in chemotherapy treatment, it causes tumor recurrence. Therefore, novel and more effective compounds are needed DOC-resistant PCa treatment. This study aimed investigate the possible cytotoxic cell death-inducing activities thymoquinone (TQ), one main active components Nigella s...
Nepeta cataria L. has been used in traditional medicine of some countries. Here the cytotoxic and apoptogenic activity of methanol extracts, n-hexane, dichloromethane, ethyl acetate, n-butanol, and acqueous extracts and the essential oil obtained from the aerial parts of the plant were evaluated with PC3, DU-145 and MCF-7 cell lines. Cell viability, histograms of PI stained fragmented DNA in ap...
This study aims to evaluate the in vitro cytotoxic and anti-migratory effects of Ficus deltoidea L. on prostate cancer cells, identify the active compound/s and characterize their mechanism of actions. Two farmed varieties were studied, var. angustifolia (FD1) and var. deltoidea (FD2). Their crude methanolic extracts were partitioned into n-hexane (FD1h, FD2h) chloroform (FD1c, FD2c) and aqueou...
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