Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies. Here, we summarize the molecular pathways that are abnormally activated by the oncoprotein. Such pathways may provide additional opportunities to ...

The proteinmethyltransferases (PMT) constitute a large and important class of enzymes that catalyze sitespecific methylation of lysine or arginine residues on histones and other proteins. Site-specific histone methylation is a critical component of chromatin regulation of gene transcription—a pathway that is often genetically altered in human cancers. Oncogenic alterations (e.g., mutations, chr...

spinal cord injury (sci) results in up regulation and/or down regulation of several genes that may affect neuronal death and subsequent loss of motor function and also neuropathic pain. to expand a practical therapy, it is essential to recognize the specific molecular pathways altered as a function of time after spinal cord injury. this will help to develop strategies for positive manipulation ...

background alcoholic hepatitis (ah) is an acute manifestation of alcoholic liver disease with high mortality rates. objectives our aim was to study the molecular mechanisms of ah. materials and methods the differentially expressed genes (degs) in liver between ah and control cases were identified by analyzing the gse28619 microarray data using t-test. the kyoto encyclopedia of genes and genomes...

background no study from india has examined pathways to care in alcohol using population systematically. objectives the present study aimed to understand the pathways to care among alcohol-dependent individuals seeking help at a tertiary care center. patients and methods it was a cross-sectional, observational study. a total of 58 subjects diagnosed with alcohol- dependence syndrome as per dsm-...

average age distribution and generation interval were investigated in four different selection pathways. i.e., sire of future sires (ss), sire of future dams (sd), dam of future sires (ds) and dam of future dams (dd). young bulls pathway (yb) is also considered as a path that affects the generation interval in sd pathway when using progeny testing program. data were collected from animal breedi...

The HER family of receptor tyrosine kinases, including EGF receptor (EGFR), HER2, HER3, and HER4, transduce growth-promoting signals in response to ligand binding to their extracellular domains (ECD). This family is deregulated in numerous cancers, withmutations in EGFR andHER2 often serving as "driver" events to activate key growth factor signaling pathways such as the RAS-ERK and PI3K-AKT pat...

Stress is a word that can be used to explain the way we feel, or it can be used to describe something that happens to someone. For most pregnant woman, pregnancy is a happy and breathtaking time, however, pregnant for some woman can be a source of stress, depression and anxiety. These factors can be risk factors for adverse outcomes for mothers and children. Anxiety in pregnancy is associated w...