Fathers make definite contributions to infant development and are now spending more time with their children than in many past decades. This article reviews the most compelling research on the developmental importance of fathers, including father-infant attachment and interaction, and differences between maternal and paternal interaction styles. Results of a long-term study of primary caregivin...

The mammalian fetus represents a semiallograft within the maternal uterus yet is not rejected. This situation is particularly pronounced in species with a hemochorial type of placentation, such as humans and rodents, where maternal tissues and blood are in direct contact with fetal trophoblast and thus potentially with paternal antigens. The main polymorphic antigens responsible for graft rejec...

We developed a protocol of noninvasive prenatal testing (NIPT), employing a higher-resolution picodroplet digital PCR, to detect genetic imbalance in maternal plasma DNA (mpDNA) caused by cell-free fetal DNA (cffDNA). In the present study, this approach was applied to four families with autosomal recessive (AR) congenital sensorineural hearing loss. First, a fraction of the fetal DNA in mpDNA w...

OBJECTIVES We sought to investigate the pattern of recurrence of congenital heart disease (CHD) where there is one or more affected first-degree relative. BACKGROUND There are little data on patterns of recurrence of different types of CHD. Analysis of a fetal series allows a high ascertainment of affected cases. METHODS We performed an analysis of referrals for detailed fetal echocardiogra...

As part of a systematic screen for novel imprinted genes of human chromosome 7 we have investigated GRB10, which belongs to a small family of adapter proteins, known to interact with a number of receptor tyrosine kinases and signalling molecules. Upon allele-specific transcription analysis involving multiple distinct splice variants in various fetal tissues, we found that human GRB10 is imprint...

background & aim: one of the factors of affecting maternal anxiety is a history of fetal death or neonatal death. this anxiety affects fetal and maternal health. by consideration the impact of anxiety on fetal and maternal health and the lack of protective activities in this field, this study was done to determine the impact of adaptation with pregnancy educational package on anxiety and matern...

Genomic imprinting, the differential expression of paternal and maternal alleles, is involved in the regulation of embryonic and fetal growth and development. In this review, we focus on the genetics of a disorder caused by a global defect in genomic imprinting, the hydatidiform mole. The ratio between the maternal and paternal genomes is critical in determining the development of both the embr...

ABSTRACT Background: The emotional bond that a mother feels towards her infant is critical to their social, emotional, and cognitive development. This concept has a major influence on an infant’s future health, and growth, so the assessment of parental-fetal attachment and related factors is of great importance. This study aimed to examine the effect of psychological intervention on attachment ...