Memorial Symposium In Memoriam: Abraham Wikler and H. Frank Fraser--Introductory Remarks Jerome H. Jaffe 14 A Steric Theory of Opioid Agonists, Antagonists, AgonistAntagonists, and Partial Agonists William R. Martin 16 Environmental Influences in the Perception of Pain Conan Kornetsky 24 Classical Conoitioning in Opiate Dependence Charles P. O'Brien, Ronald N. Ehrman, and Joseph W. Ternes 35 On...

RONALD AYLMER FISHER was born on 17 February 1890, in East Finchley. He and his twin brother, who died in infancy, were the youngest of eight children. His father, George Fisher, was a member of the well-known firm of auctioneers, Robinson and Fisher, of King Street, St James's, London. His father's family were mostly business men, but an uncle, a younger brother of his father, was placed high ...

This chapter focuses on group dynamics. We review group dynamics in five domains and examine group dynamics within the context of group development. There are many theories about the development of group dynamics, but fundamental to all of them is the notion of groups as social systems. A system is composed of elements in interaction. When group members interact with each other, they form a soc...

An associahedral set is a combinatorial object generated by Stasheff associahedra {Kn} and equipped with appropriate face and degeneracy operators. Associahedral sets are similar in many ways to simplicial or cubical sets. In this paper we give a formal definition of an associahedral set, discuss some naturally occurring examples and construct an explicit geometric diagonal ∆ : C∗(Kn) −→ C∗(Kn)...

Ronald J. Konopka Ron Konopka was found dead of an apparent heart attack in his Pasadena, CA home on February 14, 2015. Konopka was my close contemporary and began graduate school at Caltech in 1967. He published his thesis work along with his mentor Seymour Benzer in what is perhaps the single most influential paper in circadian rhythms (Konopka and Benzer, PNAS 68, 2112–2116). The field has s...

Chronic stress leads to a weakening of excitatory synaptic transmission within and between multiple brain regions. In this talk I will discuss a model in which chronic stress impairs excitatory synapses in multiple sites with cortico-mesolimbic reward circuitry thereby producing depressive-like behavioral changes, such as anhedonia. In this model, weakening of excitatory synapses within and bet...

This paper demonstrates that the standard search and matching models of equilibrium unemployment, once properly calibrated, can generate only a tiny amount of frictional wage dispersion, i.e., wage differentials among ex-ante similar workers induced purely by search frictions. The analysis is centered around a specific measure of wage dispersion— the ratio between the average wage and the lowes...