Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe herein a targeted drug delivery system that is accurately and quantitatively predicted to self-assemble into nanoparticles based on the molecular st...

Intimal hyperplasia (IH) occurs in vascular bypass grafts and is responsible for their failure. This study aimed to encapsulate high payload of atorvastatin (ATV) efficiently prevent IH, evaluate its activity towards synthetic smooth muscle cells (SMC), implicated IH progression. Poly (lactic-co-glycolic acid) microparticles (MPs) were formulated by spray-drying with three nominal drug loadings...

Dynamic loading of software components is a commonly used mechanism to achieve better flexibility and modularity in software. For an application’s runtime safety, it is important for the application to load only its intended components. However, programming mistakes may lead to failures to load a component, or even worse, to load a malicious component. Recent work has shown that these errors ar...

During the pneumatic conveying of plastic pellets, it has been observed that materials with similar physical characteristics may develop a substantial difference in pressure drop. In this work, the pressure drop in a particle-laden 2.7 meter long horizontal channel with circular cross-section is presented from an experimental perspective. Experiments are carried out for cylindrical polystyrene ...

Adsorptive membranes have many applications in removal of contaminants, such as heavy metals and organic contaminants from water. Recently, increasing concentrations of pharmaceutically active compounds, especially antibiotics, such as chlortetracycline in water and wastewater sources has raised concerns about their potentially adverse impacts on environment and human health. In this study, a s...

The effective immobilization of a transition chalcogenide co-catalyst via an in situ aqueous photo-assisted deposition technique has shown great accessibility to complex ZnIn2S4 host hierarchical nanostructured materials with homogeneous distribution. The complementary photo-assisted deposition readily deposits finely-dispersed co-catalyst particles and simultaneously generates photocatalytic h...

We report a Monte Carlo study examining the effects of two strategies for handling measurement non-invariance - modeling and ignoring non-invariant items - on structural regression coefficients between latent variables measured with item response theory models for categorical indicators. These strategies were examined across four levels and three types of non-invariance - non-invariant loadings...