Introduction: Magnetic resonance angiography of the extremities can help in the diagnosis of conditions such as peripheral arterial disease and peripheral vascular occlusion. In recent work, non-contrast-enhanced high-resolution flow-independent angiograms of the hand have been acquired with SNR-efficient balanced steady-state free precession (SSFP) imaging [1]. The simple and efficient phase-s...

Recognizing that conspicuous multiple sclerosis (MS) lesions have high intensities in both dual-echo T2 and PDweighted MR brain images, we show that it is possible to automatically determine a thresholding mechanism to locate conspicuous lesion pixels and also to identify pixels that suffer from reduced intensity due to partial volume effects. To do so, we first transform a T2-PD feature space ...

Both functional and also more recently resting state magnetic resonance imaging have become established tools to investigate functional brain networks. Most studies use these tools to compare different populations without controlling for potential differences in underlying brain structure which might affect the functional measurements of interest. Here, we adapt a simulation approach combined w...

Introduction Partial volume effects (PVEs), which arise from the relatively low spatial resolution used in dynamic susceptibility contrast (DSC) MRI, often hamper the selection of the arterial input function (AIF, the evolution of the concentration contrast agent in a brain-feeding artery). PVEs have been shown previously to lead to shape changes in the AIF (1-3). More importantly, PVEs can lea...

This article addresses the problem of the tissue type parameter estimation in brain MRI in the presence of partial volume effects. Automatic MRI brain tissue classification is hampered by partial volume effects that are caused by the finite resolution of the acquisition process. Due to this effect intensity distributions in brain MRI cannot be well modeled by a simple mixture of Gaussians and t...

BACKGROUND Dipyrone (MET, metamizole) is a non-steroidal anti-inflammatory drug commonly used both in human and in veterinary medicine. After oral administration, is broken down rapidly to metabolites which largely retain the activity of the parent drug. Its metabolites have analgesic, antipyretic and anti-inflammatory effects. RESULTS The subjects were eight healthy male Large White post-suc...

BACKGROUND Lacosamide (LCM) is a novel antiepileptic drug (AED) with potential benefit as adjunctive treatment in patients with partial-onset seizures. As yet, limited information on cognitive effects of LCM is available, especially in real-life settings. AIMS In this open clinical prospective study, the cognitive effects of LCM were evaluated when used as adjunctive antiepileptic therapy in ...