OBJECTIVES To assess the strength of thrombin formation and determine the effects of unfractionated heparin (UFH) in children during cardiac catheterization. BACKGROUND UFH reduces the thrombotic risk related to catheterization but the effects of UFH on the coagulation system in children, and proper monitoring of UFH remain unclear. METHODS We studied 42 patients aged 3-12 years undergoing ...

Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin...

Intravenous immunoglobulins cause thromboembolic events at a frequency of 2-3%. Complications of this nature can be life threatening. Nevertheless, a test for thrombogenicity such as non activated partial thromboplastin time is not mandatory for these drugs. As a result of recent incidents we have performed experiments to evaluate a modified thrombin generation test for its ability to detect mi...

A photoelectric clot timer is described. The apparatus allows a large analytic capacity, with good precision and correlation to manual methods, and can be used with capillary blood. Prothrombin analysis according to the method of Quick and Owren, the Thrombotest method, and determinations of partial thromboplastin time are applicable to the apparatus. The semiautomated procedure is extremely si...

The automated-activated coagulation time, manual-activated coagulation time and the activated partial thromboplastin time were compared to the whole blood clotting time in the measurement of hypocoagulation of heparinized blood. The normal ranges and degree of reproducibility were determined for each clotting assay. Each method was examined for its sensitivity to various concentrations of hepar...

The concentration of heparin in plasma was measured using a chromogenic substrate. It appeared that the measurement of heparin concentration in plasma was important in therapeutic control and evaluation of heparin. There was a correlation between the activated partial thromboplastin time (APTT) and heparin concentration in plasma, but since the gradients of regression line differed in each of t...

Covid-19 is a severe acute respiratory syndrome, the disease presents with ranging from asymptomatic to symptomatic illness multiple organ failure and death, can cause effect on coagulation system. This study aimed determine of covid 19 extrinsic intrinsic pathway [prothrombin time(PT), international normalized ratio (INR), activated partial thromboplastin time (APTT)] association age gende

BACKGROUND Activated partial thromboplastin time (aPTT) and antifactor Xa (anti-Xa) monitoring methods for unfractionated heparin (UFH) often disagree. The extent of discordance for those with elevated bilirubin remains unclear. Our objective was to evaluate concordance between activated aPTT and anti-Xa methods for hyperbilirubinemic patients on UFH. METHODS This was a retrospective cohort s...

The prothrombin time (PT) and activated partial thromboplastin time (APTT) are among the most commonly ordered coagulation tests. In 2005, more than 140,000 PT and more than 95,000 APTT tests were performed at Mayo Clinic. The most common indications for ordering these tests include anticoagulant monitoring, initial evaluation of hemorrhage, and, although not generally indicated, routine preope...

UNLABELLED Clot waveform analysis extends the interpretation of aPTT measurement curves. The curve is mathematically processed to obtain information about fibrin formation kinetics including semiquantitative determination of thrombin, prothrombinase and tenase activity. PATIENTS, METHOD In this study the feasibility of clot waveform analysis for monitoring of haemophilia A was investigated us...