PURPOSE Development of an improved animal model for studying skin burns in rats. METHODS Twenty-four male Wistar rats were randomly assigned to four groups (n=6): G1-Control, G2- T100°C, G3-T150°C and G4-T200°C. Two 10 x 10 mm squares were outlined with a sterile surgical marker on each side and along the vertebral column using a prepared template positioned between the anterior and posterior...

Background: Despite the advances in treating burn injuries, severity remains one of most challenging cases to be treated. As technologies advances, regenerative therapies using stem cells have been established and found effective friendly as a tool. Stromal vascular fraction (SVF), extracted from adipose tissue, has great potential for multipotent mesenchymal differentiation. Recent research de...

Burn injuries remain a significant cause of morbidity and mortality during modern military conflicts and peacekeeping operations. Considering that commercially available dressings are not designed to meet the challenges of treating combat burn wounds, DRDC Toronto has designed a novel, absorbent and medicated bi-layer wound dressing to address key requirements for treating external war wounds. ...

Skin autografting was first described by Reverdin in 1871 [1]. The clinical utility of allograft skin as a method for wound coverage followed shortly thereafter [2]. Girdner [3] was the first to report the use of allogeneic skin to cover a burn wound; however, it wasn’t until 5 years later that Thiersch [4] described the histologic anatomy of skin engraftment and later popularized the clinical ...

PURPOSE The purpose of this study was to describe the evolution of unstageable pressure ulcers (PUs) over time to determine if their healing trajectory is consistent with full- or partial-thickness wounds. DESIGN Retrospective review of electronic medical record and a clinical PU database. SUBJECTS AND SETTINGS Patients with hospital-acquired, unstageable PUs were evaluated. Subjects were c...

Chemical burns are slow healing injuries and their depth is difficult to assess. Tissue destruction continues as long as active material is present in the wound site. The routine therapy for treatment of full thickness chemical burns is early excision; it shortens hospitalization and reduces morbidity. However, presently there is no specific treatment for chemical burns of partial thickness. Th...

Conventional management of partial-thickness burn wounds includes the use of paraffin gauze dressing, frequently with topical silver-based antibacterial creams. Some creams form an overlying slough that renders wound assessment difficult and are painful upon application. An alternative to conventional management, moist exposed burn ointment (MEBO), has been proposed as a topical agent that may ...