OBJECTIVES/HYPOTHESIS To review the recent cell proliferation signal pathways in the etiopathogenesis of acquired middle ear cholesteatoma. DATA SOURCES PubMed (to September 2015). REVIEW METHODS Articles about cell proliferation signal pathways in the etiopathogenesis of acquired cholesteatoma and treatment advances were searched in the PubMed database, from which 73 were included in this ...

OBJECTIVES 1. To investigate whether systematic preservation of the intact ossicular chain in cholesteatoma surgery provides better hearing than dismantling the chain and reconstructing it. 2. To determine whether systematic preservation of the ossicular chain in cholesteatoma surgery can be performed safely. STUDY DESIGN Longitudinal parallel group study. SETTING District general hospital ...

OBJECTIVE To study the state of proliferation and apoptotic cell death in cholesteatoma. METHOD 20 cholesteatoma samples and 10 normal external ear canal skin samples were studied with immunohistochemical SABC technique and TUNEL technique. RESULT Immunohistochemical analysis using a monoclonal antibody to proliferation cell nuclear antigen (PCNA) demonstrated the presence of proliferating ...

BACKGROUND Extrdural granulation or abscess is a possible complication of chronic suppurative otitis media (CSOM) with cholesteatoma. However, due to development of newer antibiotics and advances in bacteriology and imaging techniques, the incidence of extradural granulation or abscess has significantly decreased. The present study analyzed the clinical presentation, imaging findings, and surgi...

In this paper, we report the postoperative outcomes in canal wall up procedures with second stage surgery in 40 children undergoing intervention for cholesteatoma of the middle ear. The residuals, recurrences and the hearing results were analysed. All 40 patients had a follow-up of at least five years. Of the 39 patients who underwent two staged surgery, 18 (46.1%) had a residual lesion that wa...

Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism und...

Cholesteatoma is a well-demarcated sac of keratinizing squamous epithelium in the temporal bone, which commonly characterized as “skin wrong place. The major goal surgery for cholesteatoma to make ear safe and dry with increasing concern hearing outcome patients. Two main surgical techniques employed are Canal Wall down (CWD) up Mastoidectomy (CWU). In current study, an attempt would be made ev...

A cholesteatoma is a relatively common condition within the middle ear cavity, whereas a cholesteatoma of the squamous part of the temporal bone is an exceptionally rare entity. A case of an iatrogenic cholesteatoma located in the squamous part of the temporal bone is presented, which was revealed by an intermittent purulent discharge from an opening above the right ear 20 years after retroauri...

Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-ga...