نتایج جستجو برای: paroxysmal nocturnal hemoglobinuria
تعداد نتایج: 26047 فیلتر نتایج به سال:
Deficient Biosynthesis of N-AcetylglucosaminylPhosphatidylinositol, the First hte~iiiediate of Glycosyl Phosphatidylinositol Anchor Biosynthesis, in Cell Lines Established from Patients with Paroxysmal Nocturnal Hemoglobinuria By Minoru Takahashi,* Junji Takeda,* Shinichi Hirose,$ Robert Hyman, ll Norimitsu Inoue,* Toshio Miyata,* Etsuko Ueda,~S Teruo Kitani,~ M. Edward Medof,$ and Taroh Kinosh...
Cytogenetic studies showed both 45XO and 46XY clones in the bone marrow of a 76-yr-old male with a 17-yr history of paroxysmal nocturnal hemoglobinuria (PNH). 55Fe incorporation studies demonstrated that both clones involved the hematopoietic stem cells. The loss of the Y chromosome may reflect an aging phenomenon, rather than be related to the PNH.
Deficient Biosynthesis of N-AcetylglucosaminylPhosphatidylinositol, the First hte~iiiediate of Glycosyl Phosphatidylinositol Anchor Biosynthesis, in Cell Lines Established from Patients with Paroxysmal Nocturnal Hemoglobinuria By Minoru Takahashi,* Junji Takeda,* Shinichi Hirose,$ Robert Hyman, ll Norimitsu Inoue,* Toshio Miyata,* Etsuko Ueda,~S Teruo Kitani,~ M. Edward Medof,$ and Taroh Kinosh...
The purpose of these studies was to determine the molecular basis of the phenotypic mosaicism that is a defining feature of paroxysmal nocturnal hemoglobinuria (PNH). Analysis of T cell clones from a female patient revealed four distinct phenotypes based on surface expression of glycosyl phosphatidylinositol-anchored proteins (GPI-AP). When PIG-A (the gene that is mutant in PNH) from these clon...
Budd-Chiari syndrome (BCS) is an uncommon condition induced by thrombotic or non-thrombotic obstruction of hepatic venous outflow. BCS most often occurs in patients with underlying thrombotic diathesis, including such myeloproliferative disorders (MPDs) as polycythemia vera and paroxysmal nocturnal hemoglobinuria, and pregnancy, oral contraceptives, tumors, chronic inflammatory diseases, clotti...
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