Hemolytic anemia due to immune function is one of the major causes of acquired hemolytic anemia. In recent years, as more is known about the immune system, these entities have become better understood and their treatment improved. In this section, we will discuss three areas in which this progress has been apparent. In Section I, Dr. Peter Hillmen outlines the recent findings in the pathogenesi...

precursors and progenitors to increase production of fetal hemoglobin. J Clin Invest 75: 547-557, 1985 51. Rosa RM, Bierer BE, Thomas R, Jeffrey BS, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH: A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. New Eng J Med303: 1138-1143, 1980 52. Leary M, Abramson N: Induced hyponatremia for sickle-cell crisis. Ne...

precursors and progenitors to increase production of fetal hemoglobin. J Clin Invest 75: 547-557, 1985 51. Rosa RM, Bierer BE, Thomas R, Jeffrey BS, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH: A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. New Eng J Med303: 1138-1143, 1980 52. Leary M, Abramson N: Induced hyponatremia for sickle-cell crisis. Ne...

Animals have long played an important role in education and research. In higher education, in particular, animals are used to teach systematics, anatomy, physiology, pharmacology, and psychology. Many science courses use dissection to help students understand animal anatomy and also to provide them with skills in medical operation/surgical techniques. The practice of animal dissection in labora...

INTRODUCTION The commonest form of autoimmune hemolytic anemia is characterized by the presence of antibody of the IgG immunoglobulin class on the red cell (1). These antibodies characteristically react with red cell antigens at body temperature, and they fix complement relatively inefficiently since two antibody molecules in juxtaposition are required to initiate a complement sequence (2). The...

Proteins of the Bcl2 family play a key role in controlling the activation of caspases, the proteases that dismantle the cell in programmed cell death (Adams and Cory, 1998; Korsmeyer, 1999; Vaux and Korsmeyer, 1999). Bcl2-related proteins fall into two groups that generally either repress apoptosis (Bcl2, Bcl-xL [Bcl2lL], Bcl-w [Bcl2l2], A1 and Mcl1) or promote apoptosis (Bax, Bcl-xs [Bcl2ls], ...

Electronic health record-keeping systems in the Referent Tracking paradigm use globally unique identifiers to make explicit reference to all relevant particular entities, and structure data by referring to universals and relations defined in external, commonly-used ontologies. SNePS is a general-purpose Knowledge Representation, Reasoning and Acting system with a logical language interface. We ...

the binding of proportionately larger quantities of the third component of complement (C3) to these cells. The same amount of bound C3 was found on the membranes of normal and HEMPAS cells for a given degree of lysis. Hence, the marked increase in lysis of HEMPAS cells is due to the increased adsorption of antibody and/or increased binding of C4. PNH cells bound the same amount of C4 per bound ...

the binding of proportionately larger quantities of the third component of complement (C3) to these cells. The same amount of bound C3 was found on the membranes of normal and HEMPAS cells for a given degree of lysis. Hence, the marked increase in lysis of HEMPAS cells is due to the increased adsorption of antibody and/or increased binding of C4. PNH cells bound the same amount of C4 per bound ...

In this paper, a dynamic network DEA model is developed to evaluate the potential gains in final output from a merger of two firms. The two firms are allowed to have different production technologies or share a common technology. In a beginning period each firm uses period specific inputs to produce a final output and an intermediate output that becomes an input in the production of final outpu...