Pancreatitis is notorious to cause vascular complications. While arterial complications include pseudoaneurysm formation with a propensity to bleed, venous complications can be quite myriad. Venous involvement in pancreatitis often presents with thrombosis. From time to time case reports and series of unusual venous complications associated with pancreatitis have, however, been described. In th...

CONTEXT Chronic pancreatitis is common in India. However, its risk factors are not clear. There is sparse data on the current prevalence of tropical pancreatitis in India. OBJECTIVE To undertake a prospective nationwide study of the risk factors and clinical profile of chronic pancreatitis. SETTING Thirty-two major centers from different regions of India contributed data on 1,086 patients t...

The canine pancreatic specific lipase is available as a SNAP cPL and as a quantitative test Spec cPL. Sensitivity of Spec cPL concentrations vary for mild pancreatitis (21%), moderate to severe pancreatitis (71%), and pancreatitis overall (64–94%). Currently, serum cPL concentration is considered the most specific serum biomarker for the diagnosis of pancreatitis in dogs. Specificities range fr...

OBJECTIVE The objective of the study was to investigate the association between splenectomy and acute pancreatitis. METHODS We conducted a case-control study using the database of the Taiwan National Health Insurance Program. We included 7666 subjects aged 20-84 years with first-time acute pancreatitis during the period of 1998-2011 as cases and 30 664 randomly selected subjects without acute...

A retrospective study has been made of all adult patients admitted to Manchester Royal Infirmary with exocrine pancreatic disease between 1968 and 1974, in order to define the factors which influence the variable mortality and morbidity rates in published accounts of patients with acute pancreatitis. The most plausible explanation is that some series with low mortality rates include a variable ...

BACKGROUND Acute pancreatitis in acute myeloid leukemia (AML) has been rarely associated with cytarabine therapy. This report attempts to characterize this toxicity. PATIENTS AND METHODS Criteria for pancreatitis was prospectively defined. Seven patients with pancreatitis were identified from an AML database and a clinical study at two tertiary care centers (n = 134). Their records were retro...

Pancreatitis is a significant clinical problem and the lack of effective therapeutic options means that treatment is often palliative rather than curative. A deeper understanding of the pathogenesis of both acute and chronic pancreatitis is necessary to develop new therapies. Pathological changes in pancreatitis are dependent on innate immune cell recruitment to the site of initial tissue damag...

Aim: Acute and chronic pancreatitis are inflammations of pancreatic tissue which have systemic effects and clinical presentations such as bacteremia and septic shock. Inflammatory markers have growing importance in diagnosis and identification of the severity of the pancreatitis. We aimed to determine TNF-alpha levels in acute and chronic pancreatitis and evaluate the relation between TNF-alpha...

BACKGROUND & AIMS Mitogen-activated protein kinase (MAPK) signaling in the exocrine pancreas has been extensively studied in the context of pancreatic cancer, where its potential as a therapeutic target is limited by acquired drug resistance. However, its role in pancreatitis is less understood. We investigated the role of mitogen-activated protein kinase kinase (MEK)-initiated MAPK signaling i...

BACKGROUND Capillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability. AIM To elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect ...