Pancreatic involvement is a rare condition in the patients with systemic sarcoidosis. The incidence rate of pancreatic sarcoidosis is 1-6% of the patients with systemic disease. Symptoms related to pancreas involvement are not common and may vary from nonspecific abdominal pain or nausea and weight loss to a solid mass with obstructive jaundice. There is no specific diagnostic test for pancreat...

We report a case of histopathologically proven pancreatic cancer in an 18-year-old boy. Complete blood picture revealed moderate normochromic normocytic anaemia with anisocytosis. Other laboratory results including liver function tests, renal functions tests, serum amylase, fasting blood sugar level and serum electrolytes were all of normal values. Abdominal US showed a focal mass of the pancre...

Congenital true pancreatic cysts are very rarely seen in children. We report magnetic resonance imaging features of a case of congenital true pancreatic cyst with a high level of enzymatic activity which, to the best of our knowledge, have not previously been reported. A 4-month-old boy was admitted to our clinic with a history of abdominal swelling for one month. A mobile, smooth, non-tender m...

CONTEXT The role of EUS to evaluate subtle radiographic abnormalities of the pancreas is not well defined. OBJECTIVE To assess the yield of EUS+/-FNA for focal or diffuse pancreatic enlargement/fullness seen on abdominal CT scan in the absence of discrete mass lesions. DESIGN Retrospective database review. SETTING Tertiary referral center. PATIENTS AND INTERVENTIONS Six hundred and 91 p...

A 28-year-old man presented with upper abdominal pain accompanied by loss of appetite and weight. The clinical examination was unremarkable. His laboratory investigations revealed serum alkaline phosphatase of 260IU/l (normal range: 42–126U/L) with normal serum bilirubin. Ultrasound of the abdomen showed a well-defined hypoechoic mass, measuring 3cm, in the head and body region of the pancreas ...

OBJECTIVES To evaluate the effect of solid pancreatic masses on the pancreatic duct (PD) at the endoscopic ultrasound (EUS) and the relationship of the location/size of a mass and PD dilation. MATERIALS AND METHODS Patients who underwent EUS for pancreatic indications from 2011 to 2013 at a single center were retrospectively identified. Those with biopsies that revealed adenocarcinoma or neur...

Replenishing insulin-producing pancreatic β cell mass will benefit both type I and type II diabetics. In adults, pancreatic β cells are generated primarily by self-duplication. We report on a mouse model of insulin resistance that induces dramatic pancreatic β cell proliferation and β cell mass expansion. Using this model, we identify a hormone, betatrophin, that is primarily expressed in liver...

CONTEXT Pancreatic/para-pancreatic tuberculosis is an extremely rare clinical entity even in endemic regions. It can present as a cystic or solid pancreatic mass mimicking pancreatic malignancy. There are no specific imaging criteria and the clinical symptoms remain vague. Therefore, most cases are diagnosed after surgical exploration for presumed pancreatic neoplasia. CASE REPORT We report f...

Pancreatic cancer is often detected in late stages, which contributes to its grim prognosis. Although the manifestations of pancreatic cancer most often include nonspecific gastrointestinal complaints, we report a case with the sole initial complaint of halitosis and subsequent diagnostic workup demonstrating a pancreatic mass with secondary pancreatocolonic fistulization. The etiologies of and...

Glucagon-like peptide-1 (GLP-1) receptor agonists potentiate glucose-induced insulin secretion. In addition, they have been reported to increase pancreatic beta cell mass in diabetic rodents. However, the precise mode of action of GLP-1 receptor agonists still needs to be elucidated. Here we clarify the effects of the human GLP-1 analog liraglutide on beta cell fate and function by using an ind...