The pancreas was one of the last organs in the abdomen to receive the critical attention of anatomists, physiologists, physicians, and surgeons. [1] [2] It was first referred to as the “finger of the liver” in the Talmud, written between 200 BC and 200 AD. Galen named it (though Ruphos, circa 100 AD, should probably be credited), and thought the pancreas served to support and protect blood vess...

Gastrointestinal heterotopias are rare disorders which have been identified throughout the entire length of the gastrointestinal tract. Gastric and pancreatic heterotopia has been well documented at various sites in the gastrointestinal tract, with a reported incidence of 113% [1]. Pancreatic heterotopia is mostly seen in the stomach, whereas combined (gastric and pancreatic) heterotopia is mos...

Annexins are a multigene family of calcium and phospholipid-binding proteins that play important roles in calcium signaling, cell motility, differentiation and proliferation. Our previous mass spectrometry-based proteomics study revealed that annexin A10 (ANXA10) was uniquely overexpressed in pancreatic CD24+ adenocarcinoma cells that were dissected from clinical PDAC tissues but was absent in ...

BACKGROUND Pancreatic fistula is a leading cause of morbidity and mortality after pancreaticoduodenectomy, and an external stent of pancreaticojejunostomy has been recommended to prevent pancreatic fistula. HYPOTHESIS Duct-to-mucosa pancreaticojejunostomy should not require placement of an external stent. DESIGN Nonrandomized control study. SETTING University hospital. PATIENTS Seventy-...

Gastrin is transiently expressed in fetal islets during a critical period of their development from protodifferentiated islet precursors in fetal pancreatic ducts. To examine the possible role of gastrin as an islet cell growth factor, postnatal islet growth was studied in transgenic mice which overexpress gastrin and TGF alpha in their pancreas. Overexpression of a TGF alpha transgene causes m...

The purpose of this study was to compare histologic subtype and growth pattern, including invasion and intraductal spread to branch ducts, in main duct-type intraductal papillary-mucinous carcinoma (IPMC) by histopathology and immunohistochemistry. Five surgically resected samples of main duct-type IPMC from five patients, were studied. Main lesions, invasive components, and adjacent secondary ...