Late-stage tritiation with high selectivity, isotopic purity and functional-group tolerance is important for the radiolabelling of drug candidates or bioactive compounds. Now, a broadly applicable protocol using aryl thianthrenium salts allows complex molecules by hydrogenolysis via an intermediate cationic palladium complex.

The palladium (II) bis-chelate Pd (L(1-3))(2) and platinum (II) tetranuclear Pt(4)(L(4))(4) complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass and NMR ((1)H, (13)C) spectroscopy. The complex Pd(L(2))(2) [HL(2) = m-CN-benzaldehyde thiosemicarbazone] shows a square-planar geometry with two deprotonated ligands...

A diimidazolium salt incorporating a secondary amine moiety has been used to prepare a palladium(II) di-N-heterocyclic carbene amino complex that can be deprotonated with NaH to give the first example of a transition metal NHC-amide.

The transition metal catalyzed ethylene polymerization in water suspensions has been increasingly successful in the last couple of years. Water, however, adversely affects the polymerization process by deactivating the catalyst in a Wacker-type reaction. The cationic Pd(II)-diimine Brookhart catalyst 1 is studied here by a combination of quantum mechanics and molecular mechanics to determine th...

Three new Complexes of formula [pd(bpy)(R-NH-CSS)] Cl (where bpy is 2/2′- bipyridine, and R-NH-CSS is butylamine, hexylamine- and octyamine-dithiocabamate anion) have been synthesized by University of Sistan and Blachostan. These complexes have been characterized by spectroscopic methods such as ultraviolet-visible, infrared and 1H-NMR as well as conductivity measurements and chemical analysis....

A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.

A new amphiphilic homopolymer bearing an SCS pincer palladium complex has been synthesized by reversible addition fragmentation chain transfer polymerization. The amphiphile has been shown to form spherical and worm-like micelles in water by cryogenic transmission electron microscopy and small angle neutron scattering. Segregation of reactive components within the palladium containing core resu...

The reactions of an S-bridged trinuclear palladium(II) complex, [Pd(3)(D-pen-N,O,S)(3)] (D-H(2)pen = D-penicillamine), with ethylenediamine (en) and racemic (R,R/S,S) 1,2-cyclohexanediamine (chxn) in water gave mononuclear palladium(II) complexes, [Pd(D-pen-N,S)(en)] (1) and [Pd(D-pen-N,S)(chxn)] (2), respectively. Of two diastereomers, [Pd(D-pen-N,S)(R,R-chxn)] (2(R)) and [Pd(D-pen-N,S)(S,S-ch...

A combination of hexamethyldisilane and deuterium oxide was found to work as a deuterium transfer reagent for alkynes in the presence of a catalytic amount of a palladium complex to give (E)-1,2-dideuterioalkenes selectively through the corresponding (Z)-isomer.